Recombinant Full Length Danio Rerio Alpha-2Da Adrenergic Receptor(Adra2Da) Protein, His-Tagged

• Cat.No.: RFL35558DF
• Product Overview: Recombinant Full Length Danio rerio Alpha-2Da adrenergic receptor(adra2da) Protein (Q8JG70) (1-408aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Danio rerio (Zebrafish) (Brachydanio rerio)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-408)
• AA Sequence: MSVTPTANSTEEAANITASPRLWPY TEPASAIIILVVSLIILLTIVGNVL VIVAVLTSRA LRAPQNLFLVSLACADILVATLVIP FSLANEIMGYWYFGSTWCAFYLALD VLFCTSSIVH LCAISLDRYWSVTKAVRYNLKRTPR RIKCMIAVVWLISAVISFPPLIMTK HDEKECLIND ETWYILSSCAVSFFAPGLIMITVYC KIYRVAKQRSSTVFVAKNGLERQPS QSETCFVRKD KFEKESPSSNSSESAQRQEELDDID LEESAASDSRARGSRFSKRRRVEGE RRGPQRSCRV SWAAHQEPGSRQQQLASKSKVAQMR EKRFTFVLAVVMGVFVLCWFPFFFT YSLQAVCGER CGPPEALFKLFFWIGYCNSSVNPII YTIFNRDFRKAFKKVVCWSAQRT
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: adra2da
• Synonyms: adra2da; Alpha-2Da adrenergic receptor; Alpha-2Da adrenoceptor; Alpha(2DaAR; Alpha-2Da adrenoreceptor
• UniProt ID: Q8JG70

Gene Information

• Gene Name: adra2da
• Synonyms: adra2da; Alpha-2Da adrenergic receptor; Alpha-2Da adrenoceptor; Alpha(2DaAR; Alpha-2Da adrenoreceptor
• UniProt ID: Q8JG70

Reviews

11/29/2022

the technical support provided by the manufacturer has been outstanding, and they have gone above and beyond to answer my questions and address any problems that have arisen.

12/30/2021

I am extremely satisfied with the quality of the protein and the level of support provided by the manufacturer, and I am confident that this combination will enable me to achieve my research goals with maximum efficiency and accuracy.

03/06/2020

I am pleased to report that the ADRA2DA protein I have received is of exceptional quality and is highly suitable for my experimental needs.

06/03/2019

The purity and solubility of the protein are impressive and I am confident that it will perform well in my assays.

Q&As

Can ADRA2DA dysfunction be corrected or reversed?

The extent to which ADRA2DA dysfunction can be corrected or reversed will depend on the specific condition and individual factors. While targeted medications and other interventions may help manage symptoms or slow disease progression, complete reversal of ADRA2DA dysfunction may not be possible in some cases.

How does ADRA2DA function differ in different tissues of the body?

ADRA2DA is found in various tissues throughout the body, including the brain, cardiovascular system, and kidneys. While the receptor function is broadly similar in these tissues, there may be some differences in the specific downstream effectors and signaling pathways that are activated by ADRA2DA activation, leading to different physiological responses.

What are some current limitations in the understanding of ADRA2DA?

Some current limitations in the understanding of ADRA2DA include a lack of knowledge about the precise mechanisms underlying ADRA2DA function and downstream signaling pathways, as well as the role of genetic and environmental factors in modulating receptor function. Additionally, more research is needed to determine the potential clinical applications of targeting ADRA2DA.

Can genetic variations in ADRA2DA increase the likelihood of developing certain medical conditions?

Yes, genetic variations in ADRA2DA have been associated with increased risk for certain medical conditions. For example, certain genetic polymorphisms in ADRA2DA have been linked to increased risk for hypertension and depression. However, genetic variations alone are unlikely to be the sole cause of these conditions, and other factors such as environmental and lifestyle factors may also play a role.

What are some medical conditions associated with ADRA2DA dysfunction?

Medical conditions that have been associated with ADRA2DA dysfunction or alterations in expression include hypertension, depression, anxiety, ADHD, and substance abuse disorders.

What are some potential future applications for targeting ADRA2DA?

Possible future applications for targeting ADRA2DA include the development of more effective treatments for conditions such as hypertension, mood disorders, and addiction. ADRA2DA-targeted medications could also potentially be used to improve cognitive function, enhance athletic performance, and mitigate the effects of aging.

What are some treatment options for medical conditions related to ADRA2DA dysfunction?

Treatment options for medical conditions related to ADRA2DA dysfunction may include medications that target the adrenergic system, such as alpha-2 adrenergic receptor agonists or antagonists, as well as psychotherapy and lifestyle modifications. However, treatment will depend on the specific condition and individual needs of the patient.

How does ADRA2DA dysfunction relate to mental health conditions?

ADRA2DA dysfunction has been linked to several mental health conditions, including depression, anxiety, and ADHD. Research suggests that alterations in adrenergic function, including changes in ADRA2DA levels and activity, may play a role in the development and progression of these conditions. Targeting ADRA2DA with medication may therefore be a promising treatment approach for individuals with these conditions.

How does ADRA2DA function relate to the fight or flight response?

The fight or flight response is a physiological response to stress that involves increased activity in the adrenergic system, including activation of ADRA2DA receptors. Activation of these receptors helps regulate the physiological response to stress, including blood pressure and heart rate. Dysfunction in the adrenergic system, including alterations in ADRA2DA function, may contribute to overactive or dysfunctional stress responses.

Can ADRA2DA function be modulated by diet or lifestyle factors?

Yes, diet and lifestyle factors can modulate ADRA2DA function. For example, exercise has been shown to increase ADRA2DA expression in certain tissues, while stress and poor sleep quality may impair ADRA2DA function. Dietary factors such as caffeine and alcohol may also affect ADRA2DA function.

Can ADRA2DA function affect mood and behavior?

Yes, ADRA2DA function can affect mood and behavior. The receptor is involved in the regulation of neurotransmitters such as norepinephrine and dopamine, which are important for mood and behavior. Alterations in ADRA2DA function have been implicated in depression, anxiety, and other mood disorders.

How is ADRA2DA related to medical conditions?

ADRA2DA is involved in the regulation of various physiological processes that are implicated in the development and progression of several medical conditions, including hypertension, depression, anxiety, ADHD, and addiction. Alterations in ADRA2DA function or expression may therefore contribute to the development or progression of these conditions.

How is ADRA2DA dysfunction diagnosed?

ADRA2DA dysfunction may be diagnosed through genetic testing or through measurement of receptor expression or function in biological samples. However, diagnosis may also require a comprehensive evaluation of clinical symptoms and risk factors, as well as appropriate medical testing.

Are there any natural supplements or remedies that can help regulate ADRA2DA function?

While there is limited research on natural supplements or remedies specifically targeting ADRA2DA function, some natural remedies may have indirect effects on the adrenergic system. For example, certain herbal remedies such as ashwagandha, ginseng, and rhodiola have been shown to reduce stress and improve mood, potentially impacting the adrenergic system. However, it is important to discuss the use of natural supplements with a healthcare provider to ensure they are safe and appropriate for individual use.

Are there any side effects associated with medications that target ADRA2DA?

Yes, medications that target ADRA2DA can have side effects. For example, alpha-2 adrenergic receptor agonists such as clonidine can cause drowsiness, dry mouth, and low blood pressure, while antagonists such as yohimbine can cause anxiety, increased heart rate, and high blood pressure. It is important to discuss the risks and benefits of these medications with a healthcare provider.

Is there ongoing research on ADRA2DA and its potential role in the development of medical conditions?

Yes, ongoing research continues to explore the role of ADRA2DA in the development and progression of medical conditions such as hypertension, depression, and addiction. Additionally, researchers are exploring the potential use of ADRA2DA-targeted medications for the treatment of these conditions, and the development of more targeted and effective therapies is ongoing.

How does ADRA2DA dysfunction relate to addiction?

ADRA2DA dysfunction has been implicated in the development and progression of addiction, particularly to drugs such as opioids and alcohol. Alterations in ADRA2DA expression or function may contribute to changes in the brain's reward system, leading to increased risk for addiction and difficulty quitting.