Recombinant Full Length Dog Claudin-3(Cldn3) Protein, His-Tagged

• Cat.No.: RFL34064CF
• Product Overview: Recombinant Full Length Dog Claudin-3(CLDN3) Protein (Q95KM5) (1-218aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Canis lupus familiaris (Dog) (Canis familiaris)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-218)
• AA Sequence: MSMGLEIAGTSLAVLGWLSTIVCCA LPMWRVTAFIGSSIITAQITWEGLW MNCVVQSTGQ MQCKVYDSLLALPQDLQAARALIVV SILLAAFGLLVALVGAQCTNCVQDD TAKAKITIVA GVLFLLAALLTLVPVSWSANTIIRD FYNPLVPDAQKREMGAGLYVGWAAA ALQLLGGALL CCSCPPRDKKYAPTKIVYSAPRSAG PGTSTAYDRKDYV
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: CLDN3
• Synonyms: CLDN3; Claudin-3
• UniProt ID: Q95KM5

Gene Information

• Gene Name: CLDN3
• Synonyms: CLDN3; Claudin-3
• UniProt ID: Q95KM5

Reviews

04/24/2019

The manufacturer's deep understanding of the protein and its applications enables them to promptly and effectively address any issues that may arise during my trials.

06/30/2018

It minimizes the risk of protein degradation and maximizes the effectiveness of the protein in various applications, such as cell signaling pathways or metabolic studies.

12/12/2017

This stability is particularly advantageous for long-term studies or experiments involving extended incubation periods.

Q&As

Is CLDN3 a potential target for drug delivery to specific tissues?

Researchers are exploring the use of CLDN3 as a target for drug delivery systems, aiming to enhance the specificity of drug delivery to tissues expressing high levels of CLDN3.

How does CLDN3 impact the permeability of the intestinal epithelium?

CLDN3 is involved in the tight junctions of intestinal epithelial cells, influencing the permeability of the intestinal barrier and playing a role in conditions like IBD.

In which other diseases or conditions is CLDN3 being investigated?

CLDN3 is under investigation in various conditions, including infectious diseases, where its role in tight junctions may have implications for host-pathogen interactions.

Can CLDN3 be involved in inflammatory bowel diseases (IBD)?

Yes, CLDN3 is implicated in the pathogenesis of inflammatory bowel diseases, and its expression levels are being studied as potential markers for disease severity.

How is CLDN3 linked to neurodegenerative diseases?

Altered expression of CLDN3 in the blood-brain barrier is associated with certain neurodegenerative diseases, making it a subject of interest for researchers studying these conditions.