Recombinant Full Length Human ABCC13 Protein, GST-tagged
Cat.No. : | ABCC13-769HF |
Product Overview : | Human ABCC13 full-length ORF ( ENSP00000345983, 1 a.a. - 169 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 45.9 kDa |
Protein Length : | 169 amino acids |
AA Sequence : | MLSSTQNAGG SYQRVRGALD TQKCSPEKSA SFFSKVTYSW FSRVITLGYK RPLEREDLFE LKESDSFCTA CPIFEKQWRK EVLRNQERQK VKVSCYKEAH IKKPSLLYAL WNTFKSILIQ VALFKVFADI LSFTSPLIMN YTRKVNYLMG LPCENQKITS YSQASGRDS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ABCC13 ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene [ Homo sapiens ] |
Official Symbol : | ABCC13 |
Synonyms : | ABCC13; ATP-binding cassette, sub-family C (CFTR/MRP), member 13, pseudogene; ATP binding cassette, sub family C (CFTR/MRP), member 13; ATP-binding cassette protein C13; C21orf73; PRED6 |
Gene ID : | 150000 |
MIM : | 608835 |
UniProt ID : | Q9NSE7 |
Products Types
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (11)
Ask a questionIt depends on your location, we usually use FedEx to send our products.
Including hist1h2bl, al133243.2, trim58, abcc13, bpgm, and fam210b were identified in the coexpression network
Except for ABCC12/13, the ABCCs were significantly associated with B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell infiltration
The ABCC13 gene spans approximately 70kb on human chromosome 21q11.2 and consists of 14 exons. The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues. The amino acid sequence corresponding to putative membrane-spanning domains was remarkably similar to ABCC1, ABCC2, ABCC3, and ABCC6.
While some studies have investigated the potential of ABCC13 as a biomarker for lung adenocarcinoma, further research is needed to determine its clinical utility and to confirm its specificity and sensitivity as a diagnostic and prognostic marker for this type of cancer.
The ABCC13 gene was expressed in the fetal liver at the highest level among the organs studied. While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells.
ABCC13 shares a similar structure to other MRP transporters, with three TMDs and two NBDs. Although its function is not yet fully characterized, studies suggest that it may be involved in the transport of glutathione and other conjugates.
MRP10/ABCC13 is clearly a pseudo-gene which encodes a truncated protein that is highly expressed in fetal human liver with the highest similarity to MRP2/ABCC2 but without transporting activity.
There is no clear evidence at present that ABCC13 is directly linked to colon cancer.
21q11.2-q21.1
Study data demonstrate that wheat ABCC13 is functionally important for grain development and plays an important role during detoxification of heavy metals.
Customer Reviews (3)
Write a reviewThe strip is clear and of high quality
Proper purity
Fast transportation
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