Recombinant Full Length Human ACSBG1 Protein, GST-tagged

• Cat.No.: ACSBG1-824HF
• Product Overview: Human ACSBG1 full-length ORF ( NP_055977.3, 1 a.a. - 724 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene possesses long-chain acyl-CoA synthetase activity. It is thought to play a central role in brain very long-chain fatty acids metabolism and myelinogenesis. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 107.7 kDa
• Protein Length: 724 amino acids
• AA Sequence: MPRNSGAGYG CPHGDPSMLD SRETPQESRQ DMIVRTTQEK LKTSSLTDRQ PLSKESLNHA LELSVPEKVN NAQWDAPEEA LWTTRADGRV RLRIDPSCPQ LPYTVHRMFY EALDKYGDLI ALGFKRQDKW EHISYSQYYL LARRAAKGFL KLGLKQAHSV AILGFNSPEW FFSAVGTVFA GGIVTGIYTT SSPEACQYIA YDCCANVIMV DTQKQLEKIL KIWKQLPHLK AVVIYKEPPP NKMANVYTME EFMELGNEVP EEALDAIIDT QQPNQCCVLV YTSGTTGNPK GVMLSQDNIT WTARYGSQAG DIRPAEVQQE VVVSYLPLSH IAAQIYDLWT GIQWGAQVCF AEPDALKGSL VNTLREVEPT SHMGVPRVWE KIMERIQEVA AQSGFIRRKM LLWAMSVTLE QNLTCPGSDL KPFTTRLADY LVLAKVRQAL GFAKCQKNFY GAAPMMAETQ HFFLGLNIRL YAGYGLSETS GPHFMSSPYN YRLYSSGKLV PGCRVKLVNQ DAEGIGEICL WGRTIFMGYL NMEDKTCEAI DEEGWLHTGD AGRLDADGFL YITGRLKELI ITAGGENVPP VPIEEAVKME LPIISNAMLI GDQRKFLSML LTLKCTLDPD TSDQTDNLTE QAMEFCQRVG SRATTVSEII EKKDEAVYQA IEEGIRRVNM NAAARPYHIQ KWAILERDFS ISGGELGPTM KLKRLTVLEK YKGIIDSFYQ EQK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ACSBG1 acyl-CoA synthetase bubblegum family member 1 [ Homo sapiens ]
• Official Symbol: ACSBG1
• Synonyms: ACSBG1; acyl-CoA synthetase bubblegum family member 1; long-chain-fatty-acid--CoA ligase ACSBG1; BG1; BGM; bubblegum; FLJ30320; hBG1; hsBG; KIAA0631; lipidosin; MGC14352; very long chain acyl CoA synthetase; very long-chain acyl-CoA synthetase; BG; LPD; GR-LACS
• Gene ID: 23205
• mRNA Refseq: NM_001199377
• Protein Refseq: NP_001186306
• MIM: 614362
• UniProt ID: Q96GR2

Reviews

07/19/2020

The samples provided by the manufacturer allowed me to test out different proteins before committing to a larger purchase, which was extremely helpful.

04/23/2020

The manufacturer's consistency in delivering high quality proteins has made them my go-to supplier.

08/16/2019

I was impressed by the follow-up from the manufacturer's after-sales team, who ensured that I was satisfied with my purchase.

07/09/2019

A satisfying purchase

07/13/2018

All good. Will recommand to my other colleague

Q&As

What is the relationship between ACSBG1 and insulin resistance?

ACSBG1 knockout in animal models leads to improved insulin sensitivity, and ACSBG1 expression is upregulated in insulin-resistant states.

What is the primary tissue distribution of ACSBG1 expression?

ACSBG1 is primarily expressed in the liver and adipose tissue, but is also found in other tissues such as the brain.

What is the role of ACSBG1 in insulin signaling?

ACSBG1 is involved in insulin signaling by regulating the levels of diacylglycerols, which can activate PKCε and inhibit insulin signaling.

What is the mechanism of ACSBG1 regulation by PGC-1α?

PGC-1α regulates ACSBG1 expression by interacting with PPARα to increase transcription, as well as by promoting the acetylation of histones in the ACSBG1 promoter region.

What is the role of ACSBG1 in cancer?

ACSBG1 has been found to be upregulated in several types of cancer, including breast, prostate, and liver cancer, and may play a role in tumor growth and progression.

What is the role of ACSBG1 in lipid droplet formation?

ACSBG1 is involved in the formation of lipid droplets by promoting the esterification of fatty acids into triacylglycerols.

How is the expression of ACSBG1 regulated?

ACSBG1 expression is regulated by a number of transcription factors, including SREBP1c, PPARα, and PGC-1α, which are all involved in regulating lipid metabolism.

What is the role of ACSBG1 in non-alcoholic fatty liver disease (NAFLD)?

ACSBG1 expression is upregulated in the liver of individuals with NAFLD, and ACSBG1 knockout in animal models leads to reduced hepatic steatosis.

What is the mechanism of ACSBG1 regulation by PPARα?

PPARα regulates ACSBG1 expression by binding to a specific site in the ACSBG1 promoter and increasing transcription.

What is the substrate specificity of ACSBG1?

ACSBG1 has a broad substrate specificity and can activate a variety of long-chain fatty acids.