Recombinant Full Length Human ADAM7 Protein, GST-tagged

• Cat.No.: ADAM7-889HF
• Product Overview: Human ADAM7 full-length ORF ( AAI48736.1, 1 a.a. - 754 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma. [provided by RefSeq, Oct 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 109.89 kDa
• Protein Length: 754 amino acids
• AA Sequence: MLPGCIFLMI LLIPQVKEKF ILGVEGQQLV RPKKLPLIQK RDTGHTHDDD ILKTYEEELL YEIKLNRKTL VLHLLRSREF LGSNYSETFY SMKGEAFTRH PQIMDHCFYQ GSIVHEYDSA ASISTCNGLR GFFRINDQRY LIEPVKYSDE GEHLVFKYNL RVPYGANYSC TELNFTRKTV PGDNESEEDS KIKGIHDEKY VELFIVADDT VYRRNGHPHN KLRNRIWGMV NFVNMIYKTL NIHVTLVGIE IWTHEDKIEL YSNIETTLLR FSFWQEKILK TRKDFDHVVL LSGKWLYSHV QGISYPGGMC LPYYSTSIIK DLLPDTNIIA NRMAHQLGHN LGMQHDEFPC TCPSGKCVMD SDGSIPALKF SKCSQNQYHQ YLKDYKPTCM LNIPFPYNFH DFQFCGNKKL DEGEECDCGP AQECTNPCCD AHTCVLKPGF TCAEGECCES CQIKKAGSIC RPAKDECDFP EMCTGHSPAC PKDQFRVNGF PCKNSEGYCF MGKCPTREDQ CSELFDDEAI ESHDICYKMN TKGNKFGYCK NKENRFLPCE EKDVRCGKIY CTGGELSSLL GEDKTYHLKD PQKNATVKCK TIFLYHDSTD IGLVASGTKC GEGMVCNNGE CLNMEKVYIS TNCPSQCNEN PVDGHGLQCH CEEGQAPVAC EETLHVTNIT ILVVVLVLVI VGIGVLILLV RYRKCIKLKQ VQSPPTETLG VENKGYFGDE QQIRTEPILP EIHFLNKPAS KDSRGIADPN QSAK
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAM7 ADAM metallopeptidase domain 7 [ Homo sapiens ]
• Official Symbol: ADAM7
• Synonyms: ADAM7; ADAM metallopeptidase domain 7; a disintegrin and metalloproteinase domain 7; disintegrin and metalloproteinase domain-containing protein 7; EAPI; GP 83; epididymal apical protein I; sperm maturation-related glycoprotein GP-83; GP83; GP-83; ADAM 7; ADAM-7
• Gene ID: 8756
• mRNA Refseq: NM_003817
• Protein Refseq: NP_003808
• MIM: 607310
• UniProt ID: Q9H2U9

Reviews

03/10/2022

The staff followed up the progress of my experiments in real time, and they would help me solve the problems that appeared in the experiments immediately.

03/05/2021

The customer service attitude is patient, careful answers, and detailed answers to my questions.

01/14/2021

The product user manual recorded detailed information about ADAM7 protein, which gave me more information about ADAM7.

10/05/2020

The parameters of the product I received are consistent with the product information, and the price is relatively favorable.

06/12/2019

This is a purchase that satisfies me. In WB, I got a clear ADAM7 band.

Q&As

Can you customize the ADAM7 with a specific band and a specific tag?

We can customize protein production according to your specific needs, you can discuss it with our experts first.

What physiological processes is ADAM7 involved in?

ADAM7 plays positive roles in the migration and invasion of trophoblast cells.

Is there a limit to the types of protein that can participate in the promotion?

There is no limit to this promotion.

Are instructions provided for handling the lyophilized powder?

There are relevant information in our product brochures, and you can also consult relevant questions with our experts.

Which ADAM7 is suitable for WB?

Our experts can help you choose the right product for your specific needs.

Where is the cellular localization of ADAM7?

ADAM7 is localized on the sperm surface, ADAM7 is synthesized in the epididymis and is subsequently secreted and transferred to the sperm surface.

Do you offer ADAM7 protein with other tags besides HIS and GST?

We can customize ADAM7 protein according to your specific requirements.

What is the most homologous protein of ADAM7?

ADAM7 and ADAM28 have a high degree of homology.

What methods do you typically use for protein purification?

Our commonly used purification methods include hydrophobic chromatography, affinity chromatography, ion exchange chromatography, salting out, molecular sieve, etc.

Where is ADAM7 expressed?

ADAM7 is specifically expressed in the epididymis.

What are the results of overexpressing ADAM7?

Overexpression of ADAM7 promotes cell proliferation, migration and invasion, and inhibits apoptosis.

Do the levels of ADAM7 change when ADAM2 and ADAM3 are mutated?

Yes, the level of ADAM7 will be reduced.

I plan to buy ADAM7 for WB, can I buy the corresponding antibody together?

We do not currently offer ADAM7-related antibodies, but our experts are able to advise you on antibody purchases.

Can I get more promotional discounts if I buy multiple recombinant proteins from your company?

This depends on your specific purchase quantity.