Recombinant Full Length Human AGAP2 Protein, GST-tagged
Cat.No. : | AGAP2-995HF |
Product Overview : | Human AGAP2 full-length ORF ( AAH28020.1, 1 a.a. - 836 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 116.9 kDa |
Protein Length : | 836 amino acids |
AA Sequence : | MHAQRQFVVA AVRAEVRRHE VAKQALNRLR KLAERVDDPE LQDSIQASLD SIREAVINSQ EWTLSRSIPE LRLGVLGDAR SGKSSLIHRF LTGSYQVLEK TESEQYKKEM LVDGQTHLVL IREEAGAPDA KFSGWADAVI FVFSLEDENS FQAVSRLHGQ LSSLRGEGRG GLALALVGTQ DRISASSPRV VGDARARALC ADMKRCSYYE TCATYGLNVD RVFQEVAQKV VTLRKQQQLL AACKSLPSSP SHSAASTPVA GQASNGGHTS DYSSSLPSSP NVGHRELRAE AAAVAGLSTP GSLHRAAKRR TSLFANRRGS DSEKRSLDSR GETTGSGRAI PIKQSFLLKR SGNSLNKEWK KKYVTLSSNG FLLYHPSIND YIHSTHGKEM DLLRTTVKVP GKRPPRAISA FGPSASINGL VKDMSTVQMG EGLEATTPMP SPSPSPSSLQ PPPDQTSKHL LKPDRNLARA LSTDCTPSGD LSPLSREPPP SPMVKKQRRK KLTTPSKTEG SAGQAEEENF EFLIVSSTGQ TWHFEAASFE ERDAWVQAIE SQILASLQCC ESSKVKLRTD SQSEAVAIQA IRNAKGNSIC VDCGAPNPTW ASLNLGALIC IECSGIHRNL GTHLSRVRSL DLDDWPRELT LVLTAIGNDT ANRVWESDTR GRAKPSRDSS REERESWIRA KYEQLLFLAP LSTSEEPLGR QLWAAVQAQD VATVLLLLAH ARHGPLDTSV EDPQLRSPLH LAAELAHVVI TQLLLWYGAD VAARDAQGRT ALFYARQAGS QLCADILLQH GCPGEGGSAA TTPSAATTPS ITATPSPRRR SSAASVGRAD APVALV |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 [ Homo sapiens ] |
Official Symbol : | AGAP2 |
Synonyms : | AGAP2; ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; centaurin, gamma 1, CENTG1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; cnt-g1; centaurin, gamma 1; phosphoinositide 3-kinase enhancer; phosphatidylinositol 3-kinase enhancer; phosphatidylinositol-3-kinase enhancer; GTP-binding and GTPase activating protein 2; Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2; PIKE; GGAP2; CENTG1; FLJ16430; KIAA0167 |
Gene ID : | 116986 |
mRNA Refseq : | NM_001122772 |
Protein Refseq : | NP_001116244 |
MIM : | 605476 |
UniProt ID : | Q99490 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAgap2 expression can vary among different cell types and is often regulated by a combination of transcription factors and signaling pathways.
Agap2's involvement in endocytosis can indirectly affect cell signaling by influencing the internalization and processing of cell surface receptors.
Agap2's function in endocytosis is relatively conserved across various species, reflecting its fundamental role in cellular processes.
Researchers often use techniques such as molecular biology, cell imaging, and genetic manipulations to investigate agap2's function, localization, and interactions within cells.
Disruptions in agap2 function have been implicated in certain neurological disorders, potentially affecting cellular communication and signaling.
Agap2 interacts with other proteins to promote the assembly of clathrin-coated pits on the cell membrane, facilitating the invagination and internalization of specific molecules.
Genetic variations in the AGAP2 gene have been linked to certain neurological conditions, suggesting its potential involvement in brain function.
Ongoing research aims to uncover the precise mechanisms of agap2's involvement in endocytosis and its potential implications in various diseases, including neurological disorders.
Agap2 activity can be regulated by cellular signaling pathways and post-translational modifications, affecting its role in endocytic processes.
Agap2 is present in various cells and tissues throughout the body, contributing to the cellular uptake of nutrients and signaling molecules.
Agap2 contains ANK repeat and PH domains, which are crucial for protein-protein interactions and membrane binding, respectively.
Agap2 interacts with various proteins involved in endocytosis, including clathrin and other adaptors, to orchestrate the formation of coated vesicles.
The full name of the protein is "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2."
Agap2 can be found in multiple cellular compartments, including the cell membrane and endosomal structures, due to its role in endocytosis.
The role of agap2 in endocytosis suggests it could be a potential target for drugs aimed at modulating cellular uptake processes.
Agap2's ANK repeat and PH domains suggest possible roles in protein-protein interactions and membrane binding, respectively, beyond its role in endocytosis.
Agap2 helps regulate the activity of ADP-ribosylation factor (ARF) GTPases, which are critical for initiating the assembly of clathrin-coated vesicles during endocytosis.
Agap2 helps regulate endocytosis by participating in the formation of clathrin-coated vesicles that transport molecules within cells.
While agap2 is not essential for basic cellular survival, it plays a significant role in maintaining cellular homeostasis and proper functioning.
Agap2 is a protein that plays a role in endocytosis, which is the process by which cells take in molecules from the external environment.
Customer Reviews (5)
Write a reviewProtein’s reliable behavior ensured consistent downstream analyses.
It's quality ensured reliable downstream analysis without interference.
Compatibility across a range of assays expanded our research potential significantly.
The experimental group treated with Protein AGAP2 exhibited accelerated wound healing.
Replicating outcomes across diverse cell lines emphasized the product’s consistent behavior.
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