Recombinant Full Length Human AKAP10 Protein, GST-tagged
Cat.No. : | AKAP10-1342HF |
Product Overview : | Human AKAP10 full-length ORF ( NP_009133.2, 1 a.a. - 662 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins bind to the regulatory subunits of protein kinase A (PKA) and confine the holoenzyme to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. Polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2012] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 100.2 kDa |
Protein Length : | 662 amino acids |
AA Sequence : | MRGAGPSPRQ SPRTLRPDPG PAMSFFRRKV KGKEQEKTSD VKSIKASISV HSPQKSTKNH ALLEAAGPSH VAINAISANM DSFSSSRTAT LKKQPSHMEA AHFGDLGRSC LDYQTQETKS SLSKTLEQVL HDTIVLPYFI QFMELRRMEH LVKFWLEAES FHSTTWSRIR AHSLNTVKQS SLAEPVSPSK KHETTASFLT DSLDKRLEDS GSAQLFMTHS EGIDLNNRTN STQNHLLLSQ ECDSAHSLRL EMARAGTHQV SMETQESSST LTVASRNSPA SPLKELSGKL MKSIEQDAVN TFTKYISPDA AKPIPITEAM RNDIIARICG EDGQVDPNCF VLAQSIVFSA MEQEHFSEFL RSHHFCKYQI EVLTSGTVYL ADILFCESAL FYFSEYMEKE DAVNILQFWL AADNFQSQLA AKKGQYDGQE AQNDAMILYD KYFSLQATHP LGFDDVVRLE IESNICREGG PLPNCFTTPL RQAWTTMEKV FLPGFLSSNL YYKYLNDLIH SVRGDEFLGG NVSLTAPGSV GPPDESHPGS SDSSASQSSV KKASIKILKN FDEAIIVDAA SLDPESLYQR TYAGKMTFGR VSDLGQFIRE SEPEPDVRKS KGSMFSQAMK KWVQGNTDEA QEELAWKIAK MIVSDIMQQA QYDQPLEKST KL |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AKAP10 A kinase (PRKA) anchor protein 10 [ Homo sapiens ] |
Official Symbol : | AKAP10 |
Synonyms : | AKAP10; A kinase (PRKA) anchor protein 10; A-kinase anchor protein 10, mitochondrial; D AKAP2; dual specificity A kinase anchoring protein 2; MGC9414; mitochondrial A kinase PPKA anchor protein 10; PRKA10; protein kinase A anchoring protein 10; AKAP-10; D-AKAP-2; protein kinase A-anchoring protein 10; a kinase anchor protein 10, mitochondrial; dual specificity A kinase-anchoring protein 2; dual-specificity A-kinase anchoring protein 2; D-AKAP2 |
Gene ID : | 11216 |
mRNA Refseq : | NM_007202 |
Protein Refseq : | NP_009133 |
MIM : | 604694 |
UniProt ID : | O43572 |
Products Types
◆ Recombinant Protein | ||
AKAP10-426M | Recombinant Mouse AKAP10 Protein, His (Fc)-Avi-tagged | +Inquiry |
Akap10-3021M | Recombinant Mouse Akap10, His-tagged | +Inquiry |
AKAP10-396H | Recombinant Human AKAP10 Protein, GST-tagged | +Inquiry |
AKAP10-1470M | Recombinant Mouse AKAP10 Protein | +Inquiry |
AKAP10-3022H | Recombinant Human AKAP10, His-tagged | +Inquiry |
◆ Lysates | ||
AKAP10-44HCL | Recombinant Human AKAP10 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (14)
Ask a questionAKAP10 is widely expressed in various tissues and cell types throughout the body. It is found in neurons, cardiac muscle cells, skeletal muscle cells, pancreatic beta cells, and many other cell types. Its expression in different tissues suggests its importance in regulating diverse cellular processes.
Currently, there are no specific inhibitors or activators targeting AKAP10 that are widely used in research or clinical settings. However, there is ongoing research to explore potential small molecules or compounds that can selectively modulate AKAP10 function. These studies aim to better understand the precise role of AKAP10 in different cellular processes and to develop potential therapeutic agents that can target this protein.
Yes, AKAP10 can interact with several other proteins besides the ones mentioned earlier. For example, it can interact with receptors, ion channels, and other scaffolding proteins. Some examples include the interaction of AKAP10 with G protein-coupled receptors, NMDA receptors, and L-type calcium channels. These interactions allow AKAP10 to modulate different cellular signaling pathways.
AKAP10 can be studied in the laboratory using various experimental techniques. These include molecular biology techniques to investigate its expression patterns, regulation, and interaction partners. Biochemical assays can be used to assess its enzymatic activity or binding interactions.
AKAP10 presents an interesting potential as a drug target due to its involvement in various cellular processes and its interactions with multiple signaling proteins. Targeting AKAP10 could potentially modulate PKA signaling or disrupt specific protein-protein interactions, leading to therapeutic benefits in certain diseases. However, further research is needed to fully understand the implications and feasibility of targeting AKAP10 for therapeutic purposes.
AKAP10 is a potential target for therapeutic interventions, particularly in the context of cardiovascular diseases and neurological disorders. Modulating the function or expression of AKAP10 could potentially help restore normal signaling and cellular processes in these conditions. However, the development of specific AKAP10-targeted therapies is still in the early stages, and more research is needed to fully understand its therapeutic potential.
Dysregulation of AKAP10 has been implicated in various diseases and disorders. For example, mutations in AKAP10 have been associated with cardiac hypertrophy and heart failure. In addition, alterations in AKAP10 expression or function have been observed in neurological disorders, such as schizophrenia and bipolar disorder. These findings suggest that AKAP10 plays an important role in the pathogenesis of these conditions, although further studies are needed to fully understand the underlying mechanisms.
AKAP10 protein is primarily located in the cytoplasm of cells, but it can also be found associated with different cellular compartments, including the plasma membrane, mitochondria, and endoplasmic reticulum.
AKAP10 can be regulated through various mechanisms. Its expression levels can be modulated by transcriptional regulation, post-transcriptional regulation, and post-translational modifications. For example, AKAP10 expression can be upregulated or downregulated in response to different signaling pathways or cellular stimuli. Additionally, AKAP10 can undergo phosphorylation and other modifications that may affect its binding to specific signaling molecules.
AKAP10 regulates multiple cellular processes, including neurotransmission, cardiac contractility, cellular metabolism, synaptic plasticity, and cell survival. Its involvement in these processes is mainly through the regulation of PKA signaling and the interaction with other signaling molecules.
Mutations or dysregulation of AKAP10 have been implicated in certain diseases. For example, AKAP10 variants have been associated with an increased risk of developing schizophrenia, a neuropsychiatric disorder. Additionally, alterations in AKAP10 expression have been observed in cardiac diseases, such as hypertrophy and heart failure.
AKAP10 interacts with several signaling molecules, including protein kinase A (PKA), protein kinase C (PKC), protein phosphatase 2B (calcineurin), and phosphodiesterase 4D (PDE4D). These interactions allow AKAP10 to coordinate the activities of these proteins and regulate various cellular processes.
The interactions of AKAP10 with other proteins, such as receptors, ion channels, and scaffolding proteins, have several functional consequences. By anchoring PKA and other signaling molecules to specific proteins, AKAP10 helps spatially and temporally regulate their activity. This allows for precise control of cellular processes, such as neurotransmission, cardiac function, and hormone signaling. AKAP10 interactions also play a role in organizing signaling complexes and facilitating crosstalk between different signaling pathways.
Yes, AKAP10 is involved in the regulation of cardiac function, particularly in cardiac contractility. By anchoring PKA and other signaling molecules to specific locations within cardiomyocytes, AKAP10 helps coordinate signaling events that control the contraction and relaxation of the heart muscle. Dysregulation of AKAP10 has been associated with cardiac hypertrophy and heart failure.
Customer Reviews (4)
Write a reviewWith the combination of the superior AKAP10 protein and the manufacturer's excellent support, I am confident that my experimental goals will be achieved successfully.
Their extensive knowledge and prompt assistance have consistently provided effective solutions to any issues I encounter.
In addition to the outstanding protein quality, the manufacturer's technical support team has been invaluable in resolving any challenges that arise.
The AKAP10 protein is of exceptional quality, making it an optimal choice to fulfill my experimental requirements.
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