AKAP9
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Official Full Name
A kinase (PRKA) anchor protein (yotiao) 9
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Overview
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3. -
Synonyms
AKAP9; A kinase (PRKA) anchor protein (yotiao) 9; A-kinase anchor protein 9; A kinase anchor protein; 350kDa; A kinase anchoring protein 450; AKAP9 BRAF fusion protein; AKAP120 like protein; AKAP350; AKAP450; centrosome and golgi localized protein; CG NAP; HYPERION; KIAA0803; kinase N associated protein; MU RMS 40.16A; PPP1R45; PRKA9; protein kinase A anchoring protein 9; protein phosphatase 1; regulatory subunit 45; YOTIAO; protein yotiao; protein hyperion; AKAP 120-like protein; AKAP9-BRAF fusion protein; kinase N-associated protein; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; protein phosphatase 1, regulatory subunit 45; centrosome- and Golgi-localized PKN-associated protein; AKAP-9; CG-NAP; MU-RMS-40.16A;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AKAP9-26527TH | Recombinant Human AKAP9, His-tagged | E.coli | His | ||
Human | AKAP9-405H | Recombinant Human AKAP9 Protein, GST-tagged | Wheat Germ | GST | ||
Chicken | AKAP9-7119C | Recombinant Chicken AKAP9 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
AKAP9 involved in several pathways and played different roles in them. We selected most pathways AKAP9 participated on our site, such as ARMS-mediated activation, Activation of NMDA receptor upon glutamate binding and postsynaptic events, Anchoring of the basal body to the plasma membrane, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARMS-mediated activation | SLC14A2;KLB;SPTBN1;FRS2A;FGFR1B;JAK2;CSF2RB;NETO2;PTPRA |
Activation of NMDA receptor upon glutamate binding and postsynaptic events | PDPK1A;AKAP9;CREB1B;SLC14A2;CREB1;ADCY8;DLG4;NEFLB;ADCY3 |
Anchoring of the basal body to the plasma membrane | CEP135;CP110;FGFR1OP;CCDC41;DCTN1A;CEP63;CETN2;CEP78;DCTN2 |
Assembly of the primary cilium | CC2D2A;CCT8;FBF1;CLUAP1;B9D1;CCDC41;CNGA5;SETD6;CEP72 |
Axon guidance | CXCL12;DNM2;RAC3;ARHGEF28;MET;SCN3A;NTNG1;PLXNB2;COL6A2 |
CREB phosphorylation through the activation of CaMKII | NEFLB;NETO2;SLC14A2;DLG4;CREB1B;AKAP9 |
CREB phosphorylation through the activation of Ras | NEFLB;AKAP9;DLG4;SLC14A2;PDPK1A |
Cell Cycle | MAPRE1B;ATM;MSH5;DHFR;ORC3L;PDS5A;KIF18A;GSK3AA;CDCA5 |
AKAP9 has several biochemical functions, for example, ion channel binding, potassium channel regulator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP9 itself. We selected most functions AKAP9 had, and list some proteins which have the same functions with AKAP9. You can find most of the proteins on our site.
Function | Related Protein |
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ion channel binding | SLC14A2;GPD1L;ACTN4;KCNQ3;RYR2;PKP2;AKAP6;LYN;SRI |
potassium channel regulator activity | SGK2;KCNAB1;KCNIP1;KCNIP2;KCNIP4;KCNE3;AMIGO1;KCNMB2;YWHAE |
protein binding | PGR;VPS26A;SENP6;MED4;TOP3B;GRAMD3;DLG1;PAN2;RIPK3 |
protein complex scaffold | GNB2L1;MAGI3;SEPT2;MAGI1B;DLG1;WWC3;SLC9A1;SMARCD1;MAP2K2 |
protein kinase A regulatory subunit binding | ARFGEF1;ACBD3;C2orf88;PRKACA;AKAP9;AKAP1;EZR;ARFGEF2;AKAP6 |
receptor binding | FKBP1B;GAS6;EPHX2;NRG2;FGF8B;EDA;TRDN;SLC27A2;PAOX |
AKAP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP9.
GOLGA2; KDM1A; p29991-pro_0000037946; ORF; PSTPIP1; ELF3; SMYD2; ACTR3B; PUF60; TULP3; TDP2; C1orf94; pbuO; q81mm5_bacan; ybgA
- Q&As
- Reviews
Q&As (17)
Ask a questionAKAP9 plays essential roles in cardiac development and function. It is involved in the assembly and organization of the contractile machinery in cardiomyocytes, regulation of calcium signaling, modulation of cardiac gene expression, and maintenance of proper cardiac structure. Mutations in AKAP9 have been associated with dilated cardiomyopathy and other heart-related disorders.
Yes, AKAP9 has been implicated in neurodevelopment and neuronal function. It is expressed in the developing brain and is involved in neuronal migration, axon guidance, and synapse formation. Mutations in AKAP9 have been linked to intellectual disability and neurodevelopmental disorders.
Yes, AKAP9 has been implicated in cell motility and migration. It interacts with components of the cytoskeleton, such as microtubules and myosin, to regulate cell shape, adhesion, and movement. The precise mechanisms through which AKAP9 modulates cell motility are still being investigated.
Mutations in the AKAP9 gene have been linked to various genetic disorders, such as long QT syndrome, dilated cardiomyopathy, intellectual disability, and other developmental and neurological conditions.
The expression of AKAP9 can be regulated at the transcriptional level by various factors, including transcription factors, epigenetic modifications, and signaling pathways. Additionally, post-translational modifications, such as phosphorylation, can also modulate the activity and localization of AKAP9 protein.
AKAP9 protein has been implicated in certain types of cancer. For example, alterations in AKAP9 expression have been observed in ovarian, colorectal, and breast cancer, suggesting its potential involvement in tumorigenesis. However, more research is needed to fully understand its role in cancer development and progression.
Given its involvement in cardiac function and disease, AKAP9 is a potential therapeutic target for cardiovascular disorders. However, developing specific interventions that can effectively modulate AKAP9 activity or interactions while maintaining overall cellular homeostasis remains a significant challenge and requires further research.
Currently, there are no known drugs or compounds specifically targeting AKAP9. However, research efforts are ongoing to identify small molecules or peptides that can selectively modulate the activity or interactions of AKAP9 for potential therapeutic applications.
AKAP9 protein contains several functional domains, including spectrin repeats, ankyrin repeats, and a kinase-binding domain (KBD). These domains enable AKAP9 to interact with different signaling molecules and facilitate its diverse functions.
AKAP9 has been proposed as a potential biomarker in certain diseases, such as heart failure. Increased AKAP9 expression has been associated with poor prognosis in heart failure patients. However, further studies are needed to validate its potential as a biomarker in different clinical settings.
AKAP9 protein interacts with numerous proteins, including protein kinase A (PKA), protein kinase C (PKC), protein phosphatase 2B (PP2B), microtubules, myosin, and various transcription factors.
Yes, animal models, such as mice, have been used to study the impact of AKAP9 mutations or knockout on disease phenotypes. These models can help researchers understand the underlying mechanisms, evaluate therapeutic interventions, and assess the consequences of AKAP9 dysfunction in vivo.
AKAP9 is being investigated in cancer research to understand its potential roles in tumorigenesis, metastasis, and response to therapy. Alterations in AKAP9 expression and function have been associated with various cancers, and further studies aim to elucidate the underlying mechanisms and explore its therapeutic implications in cancer treatment.
Yes, studies have reported that certain AKAP9 mutations can lead to embryonic lethality in animal models. These mutations can disrupt critical developmental processes, such as heart development or neuronal migration, resulting in severe developmental defects and embryo death.
Due to its crucial role in cellular signaling and its association with certain diseases, AKAP9 has the potential to be a therapeutic target. However, specific drugs or interventions targeting AKAP9 have not yet been developed, and further research is needed to explore this possibility.
Studying AKAP9 protein can provide insights into the spatial and temporal organization of cellular signaling networks. AKAP9 acts as a scaffold protein, bringing together different signaling molecules and enzymes to facilitate their interactions and regulate downstream signaling events. Understanding the specific interactions and functions of AKAP9 can contribute to elucidating the complexity and dynamics of cellular signaling pathways.
AKAP9 is involved in multiple cellular processes, including regulation of cell division and mitotic spindle assembly, cell migration and adhesion, calcium signaling, cAMP-PKA signaling, and gene transcription.
Customer Reviews (4)
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