Recombinant Full Length Human ALK Protein, C-Flag-tagged
Cat.No. : | ALK-1151HFL |
Product Overview : | Recombinant Full Length Human ALK Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X). |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 176.3 kDa |
AA Sequence : | MGAIGLLWLLPLLLSTAAVGSGMGT GQRAGSPAAGPPLQPREPLSYSRLQ RKSLAVDFVVPSLFRVYARD LLLPPSSSELKAGRPEARGSLALDC APLLRLLGPAPGVSWTAGSPAPAEA RTLSRVLKGGSVRKLRRAKQ LVLELGEEAILEGCVGPPGEAAVGL LQFNLSELFSWWIRQGEGRLRIRLM PEKKASEVGREGRLSAAIRA SQPRLLFQIFGTGHSSLESPTNMPS PSPDYFTWNLTWIMKDSFPFLSHRS RYGLECSFDFPCELEYSPPL HDLRNQSWSWRRIPSEEASQMDLLD GPGAERSKEMPRGSFLLLNTSADSK HTILSPWMRSSSEHCTLAVS VHRHLQPSGRYIAQLLPHNEAAREI LLMPTPGKHGWTVLQGRIGRPDNPF RVALEYISSGNRSLSAVDFF ALKNCSEGTSPGSKMALQSSFTCWN GTVLQLGQACDFHQDCAQGEDESQM CRKLPVGFYCNFEDGFCGWT QGTLSPHTPQWQVRTLKDARFQDHQ DHALLLSTTDVPASESATVTSATFP APIKSSPCELRMSWLIRGVL RGNVSLVLVENKTGKEQGRMVWHVA AYEGLSLWQWMVLPLLDVSDRFWLQ MVAWWGQGSRAIVAFDNISI SLDCYLTISGEDKILQNTAPKSRNL FERNPNKELKPGENSPRQTPIFDPT VHWLFTTCGASGPHGPTQAQ CNNAYQNSNLSVEVGSEGPLKGIQI WKVPATDTYSISGYGAAGGKGGKNT MMRSHGVSVLGIFNLEKDDM LYILVGQQGEDACPSTNQLIQKVCI GENNVIEEEIRVNRSVHEWAGGGGG GGGATYVFKMKDGVPVPLII AAGGGGRAYGAKTDTFHPERLENNS SVLGLNGNSGAAGGGGGWNDNTSLL WAGKSLQEGATGGHSCPQAM KKWGWETRGGFGGGGGGCSSGGGGG GYIGGNAASNNDPEMDGEDGVSFIS PLGILYTPALKVMEGHGEVN IKHYLNCSHCEVDECHMDPESHKVI CFCDHGTVLAEDGVSCIVSPTPEPH LPLSLILSVVTSALVAALVL AFSGIMIVYRRKHQELQAMQMELQS PEYKLSKLRTSTIMTDYNPNYCFAG KTSSISDLKEVPRKNITLIR GLGHGAFGEVYEGQVSGMPNDPSPL QVAVKTLPEVCSEQDELDFLMEALI ISKFNHQNIVRCIGVSLQSL PRFILLELMAGGDLKSFLRETRPRP SQPSSLAMLDLLHVARDIACGCQYL EENHFIHRDIAARNCLLTCP GPGRVAKIGDFGMARDIYRASYYRK GGCAMLPVKWMPPEAFMEGIFTSKT DTWSFGVLLWEIFSLGYMPY PSKSNQEVLEFVTSGGRMDPPKNCP GPVYRIMTQCWQHQPEDRPNFAIIL ERIEYCTQDPDVINTALPIE YGPLVEEEEKVPVRPKDPEGVPPLL VSQQAKREEERSPAAPPPLPTTSSG KAAKKPTAAEVSVRVPRGPA VEGGHVNMAFSQSNPPSELHRVHGS RNKPTSLWNPTYGSWFTEKPTKKNN PIAKKEPHERGNLGLEGSCT VPPNVATGRLPGASLLLEPSSLTAN MKEVPLFRLRHFPCGNVNYGYQQQG LPLEAATAPGAGHYEDTILK SKNSMNQPGPTRTRPLEQKLISEED LAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Protein Kinase |
Gene Name : | ALK ALK receptor tyrosine kinase [ Homo sapiens (human) ] |
Official Symbol : | ALK |
Synonyms : | ALK1; CD246; NBLST3 |
Gene ID : | 238 |
mRNA Refseq : | NM_004304.5 |
Protein Refseq : | NP_004295.2 |
MIM : | 105590 |
UniProt ID : | Q9UM73 |
Products Types
◆ Recombinant Protein | ||
Alk-577M | Recombinant Mouse Alk Protein, MYC/DDK-tagged | +Inquiry |
Alk-15M | Recombinant Mouse Alk Protein | +Inquiry |
ALK-02H | Recombinant Human ALK (L1196M G1202R) Protein, GST-tagged | +Inquiry |
ALK-318H | Recombinant Human ALK Protein, His (Fc)-Avi-tagged | +Inquiry |
ALK-16M | Recombinant Macaca nemestrina ALK Protein | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (17)
Ask a questionThe common mutation of ALK and other genes may affect the prognosis and therapeutic effect of lung cancer, and provide new ideas for individualized treatment.
Phosphorylation of ALK can affect its activity and signal transmission efficiency, which has an impact on the biological process of cells.
The application prospect of ALK in the treatment of breast cancer needs to be further studied and discussed, and the expression level in breast cancer cells is not clear.
The interaction between ALK and other tumor suppressor genes may affect the occurrence and development of tumors, and provide new ideas for tumor treatment.
This is involved in a variety of lung cancer signaling pathways, such as PI3K/Akt, MAPK/ERK, STAT3 and other pathways.
It is associated with lung cancer, thyroid cancer, lymphoma and neuroblastoma.
As a targeted drug, ALK is mainly used by oral administration and intravenous injection, which can help in the treatment of diseases such as lung cancer.
ALK is overexpressed in a small number of lung cancer patients and is involved in the occurrence and development of lung cancer.
The mutation may affect the prognosis and therapeutic effect of lung cancer, suggesting the importance of ALK targeted therapy.
ALK is involved in signal transduction and cell growth in nervous system tumors, and has a certain influence on the occurrence and development of nervous system tumors.
ALK plays an important role in many physiological processes such as neuron migration, embryonic development and osteoblast differentiation.
ALK can be used as one of the screening indicators for lung cancer, which can help the early diagnosis and treatment of lung cancer.
ALK is expressed in a variety of cell types such as the nervous system, lymphatic system, and immune system, and is involved in a variety of biological processes.
The regulatory mechanisms of ALK mainly include gene mutation, gene expression regulation, quality control and signal pathway regulation.
The effect of ALK targeted therapy on the prognosis of lung cancer may be related to a variety of factors, including tumor stage, pathological type, treatment regimen, etc.
ALK can be used as an important marker of targeted therapy in the treatment of lung cancer, providing an individualized treatment strategy.
The relationship between ALK and colorectal cancer is unclear and needs further study.
Customer Reviews (4)
Write a reviewALK has strict quality control and complies with relevant industry standards.
The yield of ALK is high and has good economic benefits.
The enzymatic activity of ALK reached the expected level and was able to play a role in specific reactions.
Stable and reproducible results can be obtained when experiments are performed using ALK.
Ask a Question for All ALK Products
Required fields are marked with *
My Review for All ALK Products
Required fields are marked with *
Inquiry Basket