Recombinant Full Length Human Alkaline Phosphatase, Placental Type(Alpp) Protein, His-Tagged
Cat.No. : | RFL-27321HF |
Product Overview : | Recombinant Full Length Human Alkaline phosphatase, placental type(ALPP) Protein (P05187) (23-506aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Homo sapiens (Human) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length of Mature Protein (23-506) |
AA Sequence : | IIPVEEENPDFWNREAAEALGAAKK LQPAQTAAKNLIIFLGDGMGVSTVT AARILKGQKK DKLGPEIPLAMDRFPYVALSKTYNV DKHVPDSGATATAYLCGVKGNFQTI GLSAAARFNQ CNTTRGNEVISVMNRAKKAGKSVGV VTTTRVQHASPAGTYAHTVNRNWYS DADVPASARQ EGCQDIATQLISNMDIDVILGGGRK YMFRMGTPDPEYPDDYSQGGTRLDG KNLVQEWLAK RQGARYVWNRTELMQASLDPSVTHL MGLFEPGDMKYEIHRDSTLDPSLME MTEAALRLLS RNPRGFFLFVEGGRIDHGHHESRAY RALTETIMFDDAIERAGQLTSEEDT LSLVTADHSH VFSFGGYPLRGSSIFGLAPGKARDR KAYTVLLYGNGPGYVLKDGARPDVT ESESGSPEYR QQSAVPLDEETHAGEDVAVFARGPQ AHLVHGVQEQTFIAHVMAFAACLEP YTACDLAPPA GTTD |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | ALPP |
Synonyms : | ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 |
UniProt ID : | P05187 |
Gene Name : | ALPP |
Synonyms : | ALPP; PLAP; Alkaline phosphatase, placental type; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1 |
UniProt ID : | P05187 |
Products Types
◆ Recombinant Protein | ||
ALPP-219H | Recombinant Human ALPP protein(Ile23-Asp506), His-tagged | +Inquiry |
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8347H | Native Human ALPP | +Inquiry |
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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