Recombinant Full Length Human ALPP Protein, C-Flag-tagged
Cat.No. : | ALPP-150HFL |
Product Overview : | Recombinant Full Length Human ALPP Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 55.5 kDa |
AA Sequence : | MLGPCMLLLLLLLGLRLQLSLGIIP VEEENPDFWNREAAEALGAAKKLQP AQTAAKNLIIFLGDGMGVST VTAARILKGQKKDKLGPEIPLAMDR FPYVALSKTYNVDKHVPDSGATATA YLCGVKGNFQTIGLSAAARF NQCNTTRGNEVISVMNRAKKAGKSV GVVTTTRVQHASPAGTYAHTVNRNW YSDADVPASARQEGCQDIAT QLISNMDIDVILGGGRKYMFRMGTP DPEYPDDYSQGGTRLDGKNLVQEWL AKRQGARYVWNRTELMQASL DPSVTHLMGLFEPGDMKYEIHRDST LDPSLMEMTEAALRLLSRNPRGFFL FVEGGRIDHGHHESRAYRAL TETIMFDDAIERAGQLTSEEDTLSL VTADHSHVFSFGGYPLRGSSIFGLA PGKARDRKAYTVLLYGNGPG YVLKDGARPDVTESESGSPEYRQQS AVPLDEETHAGEDVAVFARGPQAHL VHGVQEQTFIAHVMAFAACL EPYTACDLAPPAGTTDAAHPGRSVV PALLPLLAGTLLLLETATAPTRTRP LEQKLISEEDLAANDILDYKDDDDK V |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Pathways : | Folate biosynthesis, Metabolic pathways |
Gene Name : | ALPP alkaline phosphatase, placental [ Homo sapiens (human) ] |
Official Symbol : | ALPP |
Synonyms : | ALP; IAP; ALPI; PALP; PLAP; PLAP-1 |
Gene ID : | 250 |
mRNA Refseq : | NM_001632.5 |
Protein Refseq : | NP_001623.3 |
MIM : | 171800 |
UniProt ID : | P05187 |
Products Types
◆ Recombinant Protein | ||
ALPP-124H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-125H | Recombinant Human ALPP Protein, His-tagged | +Inquiry |
ALPP-329H | Recombinant Human ALPP Protein, His (Fc)-Avi-tagged | +Inquiry |
ALPP-2558H | Recombinant Human ALPP protein(31-500 aa), C-His-tagged | +Inquiry |
ALPP-219H | Recombinant Human ALPP protein(Ile23-Asp506), His-tagged | +Inquiry |
◆ Native Protein | ||
ALPP-8005H | Native Human Placental Alkaline Phosphatase | +Inquiry |
ALPP-8347H | Native Human ALPP | +Inquiry |
◆ Lysates | ||
ALPP-8893HCL | Recombinant Human ALPP 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionALPP may serve as a diagnostic biomarker for specific diseases, allowing for disease detection and monitoring, and its targeting could hold therapeutic potential in certain pathological conditions.
ALPP participates in the metabolism and turnover of its substrate(s), including the hydrolysis of phosphoester bonds and the regulation of cellular phosphate homeostasis.
ALPP regulates downstream signaling pathways and molecular interactions involved in cellular processes like phosphate metabolism, intracellular signaling, and extracellular matrix remodeling.
ALPP gene expression is regulated by transcription factors, epigenetic modifications, and signaling pathways involved in cellular homeostasis and disease processes.
ALPP is localized to specific cellular compartments, such as the plasma membrane, endoplasmic reticulum, or lysosomes, and its trafficking may be regulated by sorting signals and intracellular transport machinery.
ALPP activity can be modulated by factors such as pH, calcium, and inhibitors, which can affect its catalytic efficiency and cellular functions.
ALPP deficiency or dysregulation is associated with various diseases, including metabolic disorders, bone diseases, and certain cancers, highlighting its pathological implications.
Manipulating ALPP activity and function could offer strategies to modulate cellular processes and disease outcomes, potentially leading to therapeutic interventions and improved patient outcomes.
ALPP expression and activity exhibit dynamic changes during development, cellular differentiation, and disease progression, reflecting its roles in different physiological and pathological contexts.
ALPP shows a tissue-specific expression pattern, with higher levels in tissues such as liver, bone, and kidney, and lower levels in other organs.
Customer Reviews (3)
Write a reviewHigh-throughput screening compatibility.
Consistent protein expression analysis.
Precise protein quantification in ELISA.
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