Recombinant Full Length Human AMIGO3 Protein, GST-tagged
Cat.No. : | AMIGO3-1313HF |
Product Overview : | Human AMIGO3 full-length ORF ( NP_942015.1, 1 a.a. - 504 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | AMIGO3 (Adhesion Molecule With Ig Like Domain 3) is a Protein Coding gene. An important paralog of this gene is AMIGO1. |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 81.6 kDa |
Protein Length : | 504 amino acids |
AA Sequence : | MTWLVLLGTL LCMLRVGLGT PDSEGFPPRA LHNCPYKCIC AADLLSCTGL GLQDVPAELP AATADLDLSH NALQRLRPGW LAPLFQLRAL HLDHNELDAL GRGVFVNASG LRLLDLSSNT LRALGRHDLD GLGALEKLLL FNNRLVHLDE HAFHGLRALS HLYLGCNELA SFSFDHLHGL SATHLLTLDL SSNRLGHISV PELAALPAFL KNGLYLHNNP LPCDCRLYHL LQRWHQRGLS AVRDFAREYV CLAFKVPASR VRFFQHSRVF ENCSSAPALG LERPEEHLYA LVGRSLRLYC NTSVPAMRIA WVSPQQELLR APGSRDGSIA VLADGSLAIG NVQEQHAGLF VCLATGPRLH HNQTHEYNVS VHFPRPEPEA FNTGFTTLLG CAVGLVLVLL YLFAPPCRCC RRACRCRRWP QTPSPLQELS AQSSVLSTTP PDAPSRKASV HKHVVFLEPG RRGLNGRVQL AVAEEFDLYN PGGLQLKAGS ESASSIGSEG PMTT |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | AMIGO3 adhesion molecule with Ig-like domain 3 [ Homo sapiens ] |
Official Symbol : | AMIGO3 |
Synonyms : | AMIGO3; adhesion molecule with Ig-like domain 3; amphoterin-induced protein 3; amphoterin induced gene and open reading frame 3; alivin-3; amphoterin-induced gene and ORF 3; AMIGO-3; MGC120552 |
Gene ID : | 386724 |
mRNA Refseq : | NM_198722 |
Protein Refseq : | NP_942015 |
MIM : | 615690 |
UniProt ID : | Q86WK7 |
Products Types
◆ Recombinant Protein | ||
AMIGO3-310R | Recombinant Rat AMIGO3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMIGO3-506M | Recombinant Mouse AMIGO3 Protein, His (Fc)-Avi-tagged | +Inquiry |
AMIGO3-654R | Recombinant Rat AMIGO3 Protein | +Inquiry |
AMIGO3-0014H | Recombinant Human AMIGO3 Protein (Thr20-Thr383), C-His-tagged | +Inquiry |
AMIGO3-525H | Recombinant Human AMIGO3 protein, GST-tagged | +Inquiry |
◆ Lysates | ||
AMIGO3-8881HCL | Recombinant Human AMIGO3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMIGO3 exhibits a unique tissue-specific expression pattern, with prominent expression in the central nervous system, particularly in regions involved in neuronal development and synaptic transmission, and lower expression in other organs.
Modulation of AMIGO3 expression or activity has the potential to influence neuronal plasticity and regeneration, promoting axonal growth and functional recovery in the context of injury or neurodegenerative conditions.
AMIGO3 may play a role in the formation and maintenance of myelin sheaths in the peripheral nervous system, contributing to proper nerve conduction and insulation of axons.
The regulation of AMIGO3 expression during brain development and in response to environmental stimuli involves complex molecular mechanisms, including transcriptional regulation, epigenetic modifications, and signaling pathways that respond to cues from the local microenvironment.
Different isoforms of AMIGO3 may have distinct functions, potentially influencing cellular processes such as neurite outgrowth, synaptogenesis, and cell adhesion in a context-dependent manner.
Targeting AMIGO3 expression or activity may hold promise as a therapeutic strategy for neurological conditions or neurodegenerative diseases, and further research is needed to understand its precise role and potential therapeutic implications.
Knockout or overexpression studies of AMIGO3 have revealed its critical role in neuronal connectivity and synaptic function, affecting processes such as dendritic arborization, synapse formation, and neurotransmitter release.
AMIGO3 interacts with specific cell adhesion molecules and signaling receptors, including members of the immunoglobulin superfamily and receptor tyrosine kinases, activating downstream signaling pathways involved in axonal guidance, cytoskeletal remodeling, and synaptic plasticity.
AMIGO3 plays a crucial role in neural development and axonal outgrowth, promoting the extension and guidance of growing axons during neuronal circuit formation.
Genetic variations in the AMIGO3 gene have been associated with neurological disorders, cognitive traits, and susceptibility to certain psychiatric conditions, suggesting a role in disease susceptibility and cognitive function.
Customer Reviews (3)
Write a reviewConsistent and reliable results across different experimental conditions.
High-resolution imaging for detailed protein localization.
Precise measurement of protein activity and function.
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