Recombinant Full Length Human ARMS2 Protein, C-Flag-tagged
Cat.No. : | ARMS2-1932HFL |
Product Overview : | Recombinant Full Length Human ARMS2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes a small secreted protein specific to primates. This protein is a component of the choroidal extracellular matrix of the eye. Mutations in this gene are associated with age-related macular degeneration. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 11.3 kDa |
AA Sequence : | MLRLYPGPMVTEAEGKGGPEMASLS SSVVPVSFISTLRESVLDPGVGGEG ASDKQRSKLSLSHSMIPAAK IHTELCLPAFFSPAGTQRRFQQPQH HLTLSIIHTAAR TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
SDS-PAGE: |
Gene Name : | ARMS2 age-related maculopathy susceptibility 2 [ Homo sapiens (human) ] |
Official Symbol : | ARMS2 |
Synonyms : | ARMD8 |
Gene ID : | 387715 |
mRNA Refseq : | NM_001099667.3 |
Protein Refseq : | NP_001093137.1 |
MIM : | 611313 |
UniProt ID : | P0C7Q2 |
Products Types
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (16)
Ask a questionWhile the primary association of the ARMS2 protein is with AMD, some studies have suggested its involvement in other cellular processes such as apoptosis, cell proliferation, and lipid metabolism. However, further research is needed to fully understand these potential roles.
Yes, the ARMS2 protein has been found to interact with other proteins and cellular components within the mitochondria, including members of the mitochondrial processing peptidase (MPP) complex.
Yes, researchers have developed various animal models, such as mice and zebrafish, to study the function of the ARMS2 protein and its role in age-related macular degeneration (AMD). These models allow for the investigation of ARMS2 gene mutations and their effects on retinal structure and function.
Currently, there is no well-established link between the ARMS2 protein and systemic diseases. However, studies have suggested potential associations between ARMS2 gene variants and conditions like cardiovascular diseases and Alzheimer's disease. More research is needed to ascertain these connections and understand the underlying mechanisms.
While genetics play a significant role in AMD development, environmental factors such as smoking and diet may influence the expression or function of the ARMS2 protein. However, the exact relationship between these factors and the ARMS2 protein is still being investigated.
Currently, there are no specific drugs or therapies that directly target the ARMS2 protein. Treatment for AMD primarily focuses on managing the symptoms and preventing disease progression, such as through anti-angiogenic drugs or laser therapy.
Mutations in the ARMS2 gene have primarily been associated with age-related macular degeneration (AMD). However, there is limited evidence suggesting a possible association between ARMS2 gene mutations and other eye conditions, such as polypoidal choroidal vasculopathy and pachychoroid neovasculopathy. Further research is necessary to establish these associations.
Currently, there are no drugs or interventions specifically targeting the ARMS2 protein. Most therapeutic approaches for AMD focus on mitigating its downstream effects, such as anti-vascular endothelial growth factor (VEGF) therapies. Research is ongoing to identify potential ARMS2-targeted treatments or interventions.
Changes in ARMS2 protein expression levels can be monitored through various laboratory techniques, such as Western blotting and immunohistochemistry. These methods allow for the detection and quantification of ARMS2 protein levels in biological samples, such as retinal tissues or cells, providing insights into its expression changes over time.
The exact protein-protein interactions of the ARMS2 protein are not well-characterized. However, studies have suggested potential interactions with proteins involved in mitochondrial function, oxidative stress, and inflammation. Further research is needed to fully elucidate the protein interactions and molecular pathways involving ARMS2.
Yes, genetic variations in the ARMS2 gene have been strongly linked to the development of age-related macular degeneration (AMD), a leading cause of vision loss in older adults.
Certain genetic variations in the ARMS2 gene, such as the rs10490924 and rs11200638 single nucleotide polymorphisms (SNPs), have been identified as significant risk factors for AMD. However, their predictive value in individual risk assessment is limited due to the complex interactions between genetic and environmental factors in AMD development. Genetic testing for ARMS2 variants may provide some insights into an individual's susceptibility to AMD, but it is not currently considered a definitive diagnostic tool.
While the ARMS2 protein is primarily associated with the retina and age-related macular degeneration, it has been found in low levels in other tissues, including the brain, heart, liver, and kidney. However, its function in these tissues is not well understood.
Yes, researchers continue to study the role of the ARMS2 protein in AMD, aiming to uncover its exact function, mechanisms of action, and potential therapeutic targets. This research can potentially lead to the development of novel treatments for AMD.
Genetic variations in the ARMS2 gene can serve as biomarkers for increased susceptibility to AMD. Testing for these variations can help identify individuals who may have a higher risk of developing the disease.
The precise mechanisms by which the ARMS2 protein contributes to AMD are not yet fully understood. However, it is believed that genetic variations in the ARMS2 gene may lead to dysfunctional ARMS2 protein or altered expression levels, resulting in increased susceptibility to oxidative stress and inflammation in the retina, ultimately leading to AMD.
Customer Reviews (6)
Write a reviewIts stability and compatibility make it an excellent tool for visualizing and characterizing protein structures at high resolution.
The ARMS2 protein's sensitivity and specificity ensure precise measurements, contributing to the overall success of ELISA experiments.
the ARMS2 protein has proven to be invaluable in protein electron microscopy structure analysis.
This information is crucial for researchers in understanding the protein's behavior and interaction within their specific experimental context.
ARMS2 is known for its high purity and quality, ensuring accurate and reproducible results.
The manufacturer offers exceptional technical assistance, guiding researchers through various stages of their experiments.
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