Recombinant Full Length Human ARPC3 Protein, GST-tagged
Cat.No. : | ARPC3-1101HF |
Product Overview : | Human ARPC3 full-length ORF ( NP_005710.1, 1 a.a. - 178 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 46.9 kDa |
Protein Length : | 178 amino acids |
AA Sequence : | MPAYHSSLMD PDTKLIGNMA LLPIRSQFKG PAPRETKDTD IVDEAIYYFK ANVFFKNYEI KNEADRTLIY ITLYISECLK KLQKCNSKSQ GEKEMYTLGI TNFPIPGEPG FPLNAIYAKP ANKQEDEVMR AYLQQLRQET GLRLCEKVFD PQNDKPSKWW TCFVKRQFMN KSLSGPGQ |
Applications : | Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa [ Homo sapiens ] |
Official Symbol : | ARPC3 |
Synonyms : | ARPC3; actin related protein 2/3 complex, subunit 3, 21kDa; actin related protein 2/3 complex, subunit 3 (21 kD); actin-related protein 2/3 complex subunit 3; ARC21; p21 Arc; arp2/3 complex 21 kDa subunit; ARP2/3 protein complex subunit p21; p21-Arc |
Gene ID : | 10094 |
mRNA Refseq : | NM_005719 |
Protein Refseq : | NP_005710 |
MIM : | 604225 |
UniProt ID : | O15145 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (7)
Ask a questionYes, the ARPC3 protein is essential for cell viability as it is a core component of the ARP2/3 complex, which is crucial for actin polymerization and cytoskeletal organization.
The ARPC3 protein is involved in a wide range of cellular processes that require actin dynamics, such as cell motility, endocytosis, cell division, and formation of cellular protrusions like lamellipodia and filopodia.
The ARPC3 protein can be regulated through various mechanisms. Factors such as phosphorylation, protein-protein interactions, and post-translational modifications can modulate its activity and influence actin dynamics in cells.
Targeting the ARPC3 protein or the ARP2/3 complex could have potential therapeutic implications for diseases characterized by dysregulated actin dynamics, such as cancer metastasis, autoimmune disorders, and neurodegenerative diseases. Developing specific inhibitors or modulators of ARPC3 activity could be explored as potential therapeutic strategies.
Mutations or dysregulation of the ARPC3 gene have been linked to developmental disorders and genetic syndromes, including Baraitser-Winter syndrome and distal arthrogryposis.
The ARPC3 protein interacts with other components of the ARP2/3 complex, such as ARPC1, ARPC2, ARPC4, and ARPC5, to form a functional actin nucleation complex. It also interacts with various actin-binding proteins and regulators to mediate actin dynamics.
Researchers can study the ARPC3 protein by using techniques such as immunoblotting, immunofluorescence microscopy, co-immunoprecipitation, and gene knockout or knockdown approaches in cell culture models to assess its expression, localization, interactions, and functional effects.
Customer Reviews (3)
Write a reviewthe ARPC3 protein finds great utility in protein electron microscopy structure analysis, consistently delivering exceptional results.
Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.
Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.
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