Recombinant Full Length Human ASB9 Protein, GST-tagged

• Cat.No.: ASB9-1364HF
• Product Overview: Human ASB9 full-length ORF ( AAH01244, 1 a.a. - 252 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 53.46 kDa
• Protein Length: 252 amino acids
• AA Sequence: MDGKQGGMDG SKPAGPRDFP GIRLLSNPLM GDAVSDWSPM HEAAIHGHQL SLRNLISQGW AVNIITADHV SPLHEACLGG HLSCVKILLK HGAQVNGVTA DWHTPLFNAC VSGSWDCVNL LLQHGASVQP ESDLASPIHE AARRAYGGNI DHKISHLGTP LYLACENQQR ACVKKLLESG ADVNQGKGQD SPLHAVARTA SEELACLLMD FGADTQAKNA EGKRPVELVP PESPLAQLFL EREGASLPKP KP
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ASB9 ankyrin repeat and SOCS box containing 9 [ Homo sapiens ]
• Official Symbol: ASB9
• Synonyms: ASB9; ankyrin repeat and SOCS box containing 9; ankyrin repeat and SOCS box protein 9; DKFZP564L0862; FLJ20636; MGC4954; ASB-9; ankyrin repeat and SOCS box-containing 9; ankyrin repeat and suppressor of cytokine signaling box protein 9; DKFZp564L0862
• Gene ID: 140462
• mRNA Refseq: NM_001031739
• Protein Refseq: NP_001026909
• MIM: 300890
• UniProt ID: Q96DX5

Reviews

08/05/2017

Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

05/21/2017

The manufacturer of ASB9 protein plays a crucial role in supporting my research endeavors.

10/06/2016

the ASB9 protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.

Q&As

Does ASB9 play a role in cellular processes such as cell proliferation or differentiation?

The precise role of ASB9 in cellular processes such as cell proliferation or differentiation is not well-established. However, its involvement in protein degradation suggests it may influence various aspects of cellular homeostasis.

Are there any disease associations with ASB9?

Currently, there are no specific diseases directly associated with ASB9. However, dysregulation of protein degradation pathways, in which ASB9 is involved, can contribute to various pathological conditions.

Where is ASB9 localized within the cell?

ASB9 is primarily localized in the cytoplasm of cells. However, it may also shuttle between the cytoplasm and nucleus, depending on specific cellular signaling events.

What are the known interacting partners of ASB9?

ASB9 interacts with several proteins, such as Cullin-5 (CUL5) and Elongin BC complex, to form an E3 ubiquitin-protein ligase complex. It also interacts with specific target substrates for degradation.