Recombinant Mouse Asb9 Protein, Myc/DDK-tagged

• Cat.No.: Asb9-1736M
• Product Overview: Purified recombinant protein of mouse full-length ankyrin repeat and SOCS box-containing 9 (Asb9), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 31.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Asb9 ankyrin repeat and SOCS box-containing 9 [ Mus musculus (house mouse) ]
• Official Symbol: Asb9
• Synonyms: ASB9; ankyrin repeat and SOCS box-containing 9; ankyrin repeat and SOCS box protein 9; ASB-9; ankyrin repeat and SOCS box-containing protein 9; 1700011M07Rik
• Gene ID: 69299
• mRNA Refseq: NM_027027
• Protein Refseq: NP_081303
• UniProt ID: Q91ZT8

Reviews

08/05/2017

Its ability to bind to negatively charged phospholipids, particularly during blood clot formation, has made it invaluable for in vitro and in vivo investigations of hemostatic mechanisms.

05/21/2017

The manufacturer of ASB9 protein plays a crucial role in supporting my research endeavors.

10/06/2016

the ASB9 protein is known for its strong affinity for phospholipids, particularly phosphatidylserine (PS), on the outer leaflet of cell membranes.

Q&As

Does ASB9 play a role in cellular processes such as cell proliferation or differentiation?

The precise role of ASB9 in cellular processes such as cell proliferation or differentiation is not well-established. However, its involvement in protein degradation suggests it may influence various aspects of cellular homeostasis.

Are there any disease associations with ASB9?

Currently, there are no specific diseases directly associated with ASB9. However, dysregulation of protein degradation pathways, in which ASB9 is involved, can contribute to various pathological conditions.

Where is ASB9 localized within the cell?

ASB9 is primarily localized in the cytoplasm of cells. However, it may also shuttle between the cytoplasm and nucleus, depending on specific cellular signaling events.

What are the known interacting partners of ASB9?

ASB9 interacts with several proteins, such as Cullin-5 (CUL5) and Elongin BC complex, to form an E3 ubiquitin-protein ligase complex. It also interacts with specific target substrates for degradation.