Recombinant Full Length Human ASCL2 Protein, C-Flag-tagged
Cat.No. : | ASCL2-1467HFL |
Product Overview : | Recombinant Full Length Human ASCL2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene is a member of the basic helix-loop-helix (BHLH) family of transcription factors. It activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. Involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 20 kDa |
AA Sequence : | MDGGTLPRSAPPAPPVPVGCAARRR PASPELLRCSRRRRPATAETGGGAA AVARRNERERNRVKLVNLGF QALRQHVPHGGASKKLSKVETLRSA VEYIRALQRLLAEHDAVRNALAGGL RPQAVRPSAPRGPPGTTPVA ASPSRASSSPGRGGSSEPGSPRSAY SSDDSGCEGALSPAERELLDFSSWL GGYSGPTRTRPLEQKLISEEDLAAN DILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transcription Factors |
Gene Name : | ASCL2 achaete-scute family bHLH transcription factor 2 [ Homo sapiens (human) ] |
Official Symbol : | ASCL2 |
Synonyms : | ASH2; HASH2; MASH2; bHLHa45 |
Gene ID : | 430 |
mRNA Refseq : | NM_005170.3 |
Protein Refseq : | NP_005161.1 |
MIM : | 601886 |
UniProt ID : | Q99929 |
Products Types
◆ Recombinant Protein | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionASCL2, along with other transcription factors and signaling molecules, has been used in combination to induce cellular reprogramming and pluripotency in certain contexts, demonstrating its ability to alter cell fate.
ASCL2's primary role is in the gastrointestinal tract, but it may also have roles in other tissues and organs during development, including lung and pancreas.
ASCL2 interacts with various co-factors and proteins involved in stem cell regulation and development, including β-catenin, POU5F1 (Oct4), and SMAD proteins.
Yes, ASCL2 is crucial for the normal development of the gastrointestinal tract, particularly in regulating the differentiation and proliferation of intestinal stem cells.
ASCL2 is being explored as a potential therapeutic target for colorectal cancer due to its involvement in promoting abnormal cell proliferation. Targeting ASCL2 may help inhibit tumor growth and progression.
ASCL2 promotes the self-renewal of intestinal stem cells by activating specific gene expression programs involved in stem cell maintenance. It also regulates the balance between proliferation and differentiation of these cells.
Customer Reviews (3)
Write a reviewThe manufacturer's commitment to providing excellent technical support is highly valuable.
The combination of high-quality ASCL2 protein and excellent technical support provided by the manufacturer makes them the ideal choice for my research.
The ASCL2 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
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