Recombinant Full Length Human ATP2A3 Protein, C-Flag-tagged
Cat.No. : | ATP2A3-1885HFL |
Product Overview : | Recombinant Full Length Human ATP2A3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells. |
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Description : | This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | Mammalian cells |
Species : | Human |
Tag : | Flag |
Form : | 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : | 114.8 kDa |
AA Sequence : | MEAAHLLPAADVLRHFSVTAEGGLS PAQVTGARERYGPNELPSEEGKSLW ELVLEQFEDLLVRILLLAAL VSFVLAWFEEGEETTTAFVEPLVIM LILVANAIVGVWQERNAESAIEALK EYEPEMGKVIRSDRKGVQRI RARDIVPGDIVEVAVGDKVPADLRL IEIKSTTLRVDQSILTGESVSVTKH TEAIPDPRAVNQDKKNMLFS GTNITSGKAVGVAVATGLHTELGKI RSQMAAVEPERTPLQRKLDEFGRQL SHAISVICVAVWVINIGHFA DPAHGGSWLRGAVYYFKIAVALAVA AIPEGLPAVITTCLALGTRRMARKN AIVRSLPSVETLGCTSVICS DKTGTLTTNQMSVCRMFVVAEADAG SCLLHEFTISGTTYTPEGEVRQGDQ PVRCGQFDGLVELATICALC NDSALDYNEAKGVYEKVGEATETAL TCLVEKMNVFDTDLQALSRVERAGA CNTVIKQLMRKEFTLEFSRD RKSMSVYCTPTRPHPTGQGSKMFVK GAPESVIERCSSVRVGSRTAPLTPT SREQILAKIRDWGSGSDTLR CLALATRDAPPRKEDMELDDCSKFV QYETDLTFVGCVGMLDPPRPEVAAC ITRCYQAGIRVVMITGDNKG TAVAICRRLGIFGDTEDVAGKAYTG REFDDLSPEQQRQACRTARCFARVE PAHKSRIVENLQSFNEITAM TGDGVNDAPALKKAEIGIAMGSGTA VAKSAAEMVLSDDNFASIVAAVEEG RAIYSNMKQFIRYLISSNVG EVVCIFLTAILGLPEALIPVQLLWV NLVTDGLPATALGFNPPDLDIMEKL PRSPREALISGWLFFRYLAI GVYVGLATVAAATWWFVYDAEGPHI NFYQLRNFLKCSEDNPLFAGIDCEV FESRFPTTMALSVLVTIEMC NALNSVSENQSLLRMPPWMNPWLLV AVAMSMALHFLILLVPPLPLIFQVT PLSGRQWVVVLQISLPVILL DEALKYLSRNHMHACLYPGLLRTVS QAWSRQPLTTSWTPDHTGLASLGQG HSIVSLSELLREGGSREEMS QK TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade. |
Concentration : | >50 ug/mL as determined by microplate BCA method. |
Preparation : | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : | Druggable Genome, Transmembrane |
Protein Pathways : | Alzheimer's disease, Calcium signaling pathway |
Gene Name : | ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [ Homo sapiens (human) ] |
Official Symbol : | ATP2A3 |
Synonyms : | SERCA3 |
Gene ID : | 489 |
mRNA Refseq : | NM_174953.3 |
Protein Refseq : | NP_777613.1 |
MIM : | 601929 |
UniProt ID : | Q93084 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionMutations in the recombinant ATP2A3 protein may lead to abnormal changes in its intracellular localization and function, thereby affecting the normal function of cardiomyocytes.
Certain drugs can affect the function of ATP2A3 recombinant protein, such as calcium modulators and cardiovascular drugs. These drugs may affect the intracellular calcium balance and the normal function of the cardiovascular system.
Yes, the expression and function of ATP2A3 recombinant protein in the heart are regulated by complex regulatory mechanisms, including endogenous signaling pathways and regulation of the cardiovascular system.
ATP2A3 recombinant protein is mainly expressed in muscle tissue, heart, kidney and other tissues and organs in the human body.
Yes, mutations in ATP2A3 recombinant protein may be associated with certain cardiovascular diseases (such as myocardial infarction, heart failure, etc.).
The main role of ATP2A3 recombinant protein in the heart is to regulate the intracellular calcium balance of muscle cells and participate in the regulation of myocardial contraction and relaxation.
Customer Reviews (3)
Write a reviewThe green production process of ATP2A3 is very environmentally friendly. From the selection of raw materials to the production process, it reflects the concept of green production, without any negative impact on the environment.
Its repeatability can be said to be unparalleled, and the consistent results in every experiment or application is an important manifestation of its superior quality.
ATP2A3 has a short half-life and high clearance, making it more advantageous in emergency situations where a rapid therapeutic effect is required.
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