Recombinant Human ATP2A3 Protein, MYC/DDK-tagged

• Cat.No.: ATP2A3-2942H
• Product Overview: Recombinant Human ATP2A3 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 114.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: ATP2A3 ATPase, Ca++ transporting, ubiquitous [ Homo sapiens ]
• Official Symbol: ATP2A3
• Synonyms: SERCA3
• Gene ID: 489
• mRNA Refseq: NM_005173
• Protein Refseq: NP_005164
• MIM: 601929
• UniProt ID: Q93084

Reviews

09/19/2022

The green production process of ATP2A3 is very environmentally friendly. From the selection of raw materials to the production process, it reflects the concept of green production, without any negative impact on the environment.

04/02/2020

Its repeatability can be said to be unparalleled, and the consistent results in every experiment or application is an important manifestation of its superior quality.

01/31/2019

ATP2A3 has a short half-life and high clearance, making it more advantageous in emergency situations where a rapid therapeutic effect is required.

Q&As

What is the mutation mechanism of ATP2A3 recombinant protein?

Mutations in the recombinant ATP2A3 protein may lead to abnormal changes in its intracellular localization and function, thereby affecting the normal function of cardiomyocytes.

Does the recombinant ATP2A3 protein interact with specific drugs?

Certain drugs can affect the function of ATP2A3 recombinant protein, such as calcium modulators and cardiovascular drugs. These drugs may affect the intracellular calcium balance and the normal function of the cardiovascular system.

Are the expression and function of ATP2A3 recombinant protein regulated in the heart?

Yes, the expression and function of ATP2A3 recombinant protein in the heart are regulated by complex regulatory mechanisms, including endogenous signaling pathways and regulation of the cardiovascular system.

What is the expression pattern of the recombinant ATP2A3 protein in humans?

ATP2A3 recombinant protein is mainly expressed in muscle tissue, heart, kidney and other tissues and organs in the human body.

Are mutations in the recombinant ATP2A3 protein associated with human cardiovascular disease?

Yes, mutations in ATP2A3 recombinant protein may be associated with certain cardiovascular diseases (such as myocardial infarction, heart failure, etc.).

What is the function of ATP2A3 recombinant protein in the heart?

The main role of ATP2A3 recombinant protein in the heart is to regulate the intracellular calcium balance of muscle cells and participate in the regulation of myocardial contraction and relaxation.