Recombinant Full Length Human ATP9A Protein, GST-tagged

• Cat.No.: ATP9A-1098HF
• Product Overview: Human ATP9A full-length ORF ( NP_006036.1, 1 a.a. - 1047 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: ATP9A (ATPase Phospholipid Transporting 9A (Putative)) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include nucleotide binding and cation-transporting ATPase activity. An important paralog of this gene is ATP9B.
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 145 kDa
• Protein Length: 1047 amino acids
• AA Sequence: MTDNIPLQPV RQKKRMDSRP RAGCCEWLRC CGGGEARPRT VWLGHPEKRD QRYPRNVINN QKYNFFTFLP GVLFNQFKYF FNLYFLLLAC SQFVPEMRLG ALYTYWVPLG FVLAVTVIRE AVEEIRCYVR DKEVNSQVYS RLTARGTVKV KSSNIQVGDL IIVEKNQRVP ADMIFLRTSE KNGSCFLRTD QLDGETDWKL RLPVACTQRL PTAADLLQIR SYVYAEEPNI DIHNFVGTFT REDSDPPISE SLSIENTLWA GTVVASGTVV GVVLYTGREL RSVMNTSNPR SKIGLFDLEV NCLTKILFGA LVVVSLVMVA LQHFAGRWYL QIIRFLLLFS NIIPISLRVN LDMGKIVYSW VIRRDSKIPG TVVRSSTIPE QLGRISYLLT DKTGTLTQNE MIFKRLHLGT VAYGLDSMDE VQSHIFSIYT QQSQDPPAQK GPTLTTKVRR TMSSRVHEAV KAIALCHNVT PVYESNGVTD QAEAEKQYED SCRVYQASSP DEVALVQWTE SVGLTLVGRD QSSMQLRTPG DQILNFTILQ IFPFTYESKR MGIIVRDEST GEITFYMKGA DVVMAGIVQY NDWLEEECGN MAREGLRVLV VAKKSLAEEQ YQDFEARYVQ AKLSVHDRSL KVATVIESLE MEMELLCLTG VEDQLQADVR PTLETLRNAG IKVWMLTGDK LETATCTAKN AHLVTRNQDI HVFRLVTNRG EAHLELNAFR RKHDCALVIS GDSLEVCLKY YEYEFMELAC QCPAVVCCRC APTQKAQIVR LLQERTGKLT CAVGDGGNDV SMIQESDCGV GVEGKEGKQA SLAADFSITQ FKHLGRLLMV HGRNSYKRSA ALSQFVIHRS LCISTMQAVF SSVFYFASVP LYQGFLIIGY STIYTMFPVF SLVLDKDVKS EVAMLYPELY KDLLKGRPLS YKTFLIWVLI SIYQGSTIMY GALLLFESEF VHIVAISFTS LILTELLMVA LTIQTWHWLM TVAELLSLAC YIASLVFLHE FIDVYFIATL SFLWKVSVIT LVSCLPLYVL KYLRRRFSPP SYSKLTS
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ATP9A ATPase, class II, type 9A [ Homo sapiens ]
• Official Symbol: ATP9A
• Synonyms: ATP9A; ATPase, class II, type 9A; ATPase, Class II, type 9A; probable phospholipid-transporting ATPase IIA; ATPIIA; KIAA0611; phospholipid-transporting ATPase IIA; ATPase type IV, phospholipid-transporting (P-type),(putative)
• Gene ID: 10079
• mRNA Refseq: NM_006045
• Protein Refseq: NP_006036
• MIM: 609126
• UniProt ID: O75110

Reviews

10/08/2022

The stability of ATP9A is very stable under a variety of environmental conditions, whether it is low temperature, high temperature, or other extreme environments, and its performance remains consistent.

06/01/2021

As the production process of ATP9A adopts the most advanced biotechnology, the production process is more green and sustainable.

11/27/2019

Due to the short half-life and high clearance rate of recombinant proteins, their rapid clearance from the body reduces the risk of side effects.

Q&As

What is the expression pattern of ATP9A gene?

ATP9A gene is widely expressed in various human tissues. However, its expression levels may vary in different tissues and cell types.

How to detect ATP9A gene mutation?

Detection of ATP9A gene mutations is usually performed by gene sequencing technology. Common methods include Sanger sequencing, next generation sequencing (NGS), etc. These methods can detect point mutations, insertion/deletion mutations and so on on ATP9A gene.

Does ATP9A gene mutation affect cell membrane stability?

The protein is involved in the phospholipid turnover process of cell membrane and maintains the stability of cell membrane. ATP9A gene mutation may lead to abnormal protein function, and then affect the stability of cell membrane.

What is the effect of ATP9A gene mutation on treatment?

Currently, there is no specific therapy targeting ATP9A gene mutations. However, understanding the mutation status of ATP9A gene can help doctors better understand the disease risk and prognosis of patients to develop individualized treatment plans.

How do ATP9A gene mutations affect the function of ATP9A protein?

This gene mutation may lead to the structural and functional abnormalities of ATP9A protein, affecting the phospholipid turnover process of the inner and outer membranes of cells. This may negatively affect the function and stability of the cells.

How do ATP9A mutations affect nervous system development?

The effects of specific ATP9A gene mutations on nervous system development are unknown. However, several studies have shown that ATP9A protein plays an important role in nerve cells, and mutations may be associated with intellectual disability and neurodevelopmental abnormalities.