Recombinant Full Length Human AVPR1B Protein

• Cat.No.: AVPR1B-1545HF
• Product Overview: Human AVPR1B full-length ORF (AAI56079.1) recombinant protein without tag.

Specification

• Description: The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 46.7 kDa
• Protein Length: 424 amino acids
• AA Sequence: MDSGPLWDAN PTPRGTLSAP NATTPWLGRD EELAKVEIGV LATVLVLATG GNLAVLLTLG QLGRKRSRMH LFVLHLALTD LAVALFQVLP QLLWDITYRF QGPDLLCRAV KYLQVLSMFA STYMLLAMTL DRYLAVCHPL RSLQQPGQST YLLIAAPWLL AAIFSLPQVF IFSLREVIQG SGVLDCWADF GFPWGPRAYL TWTTLAIFVL PVTMLTACYS LICHEICKNL KVKTQAWRVG GGGWRTWDRP SPSTLAATTR GLPSRVSSIN TISRAKIRTV KMTFVIVLAY IACWAPFFSV QMWSVWDKNA PDEDSTNVAF TISMLLGNLN SCCNPWIYMG FNSHLLPRPL RHLACCGGPQ PRMRRRLSDG SLSSRHTTLL TRSSCPATLS LSLSLTLSGR PRPEESPRDL ELADGEGTAE TIIF
• Applications: Antibody Production; Functional Study; Compound Screening
• Usage: Heating may cause protein aggregation. Please do not heat this product before electrophoresis.
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 25 mM Tris-HCl of pH8.0 containing 2% glycerol.

Gene Information

• Gene Name: AVPR1B arginine vasopressin receptor 1B [ Homo sapiens ]
• Official Symbol: AVPR1B
• Synonyms: AVPR1B; arginine vasopressin receptor 1B; AVPR3; vasopressin V1b receptor; V1bR; AVPR V3; AVPR V1b; vasopressin V3 receptor; arginine vasopressin receptor 3; antidiuretic hormone receptor 1B; pituitary vasopressin receptor 3
• Gene ID: 553
• mRNA Refseq: NM_000707
• Protein Refseq: NP_000698
• MIM: 600264
• UniProt ID: P47901

Reviews

10/27/2022

The solubility is very good and can be easily dissolved in various buffers.

07/06/2021

Storage conditions are very simple and can be stored for a long time.

01/08/2020

Anti-pollution ability is very strong, not easy to be contaminated.

Q&As

Which hormone does AVPR1B protein bind to?

The AVPR1B protein binds to arginine vasopressin and, through its binding to arginine vasopressin, triggers the activation of intracellular signal transduction pathways.

What are the prospects of AVPR1B protein in drug development?

AVPR1B has been implicated in a variety of neuropsychiatric disorders, and it is considered as a potential drug development target. Researchers are exploring the development of drugs that interact with AVPR1B protein for the treatment of related diseases.

What signal transduction pathways do AVPR1B proteins associate with?

AVPR1B protein is associated with a variety of signal transduction pathways, including G protein-coupled receptor signal transduction, phosphatidylinositol signal transduction, protein kinase C signal transduction, etc.

In which tissues is AVPR1B protein expressed?

The protein is mainly expressed in the central nervous system, including areas such as the anterior pituitary, hypothalamus, and hippocampus, and is also expressed at low levels in the adrenal gland and other tissues.

What are the structural features of the AVPR1B protein?

The AVPR1B protein is a seven-fold transmembrane receptor protein with an N-terminal external domain and a C-terminal internal domain. The N-terminal external domain contains the site for binding to arginine vasopressin.

What is the role of AVPR1B protein in stress response?

The protein is involved in the regulation of stress response by increasing the release of corticotrophin from the anterior pituitary in the central nervous system and regulating the levels of stress hormones, thereby affecting the generation and regulation of stress response.