Recombinant Full Length Human CDK2AP1 Protein, GST-tagged
Cat.No. : | CDK2AP1-3179HF |
Product Overview : | Human CDK2AP1 full-length ORF (AAH34717, 1 a.a. - 115 a.a.) recombinant protein with GST-tag at N-terminal. |
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Description : | The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012] |
Source : | In Vitro Cell Free System |
Species : | Human |
Tag : | GST |
Molecular Mass : | 38.39 kDa |
Protein Length : | 115 amino acids |
AA Sequence : | MSYKPNLAAHMPAAALNAAGSVHSP STSMATSSQYRQLLSDYGPPSLGYT QGTGNSQVPQSKYAELLAIIEELGK EIRPTYAGSKSAMERLKRGIIHARG LVRECLAETERNARS |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | CDK2AP1 cyclin-dependent kinase 2 associated protein 1 [ Homo sapiens ] |
Official Symbol : | CDK2AP1 |
Synonyms : | CDK2AP1; cyclin-dependent kinase 2 associated protein 1; CDK2 associated protein 1; cyclin-dependent kinase 2-associated protein 1; doc 1; DOC1; DORC1; p12DOC 1; ST19; Deleted in oral cancer-1; deleted in oral cancer 1; CDK2-associated protein 1; putative oral cancer suppressor; doc-1; p12DOC-1; |
Gene ID : | 8099 |
mRNA Refseq : | NM_004642 |
Protein Refseq : | NP_004633 |
MIM : | 602198 |
UniProt ID : | O14519 |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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