Recombinant Full Length Human CDK9 Protein, GST-tagged

• Cat.No.: CDK9-3165HF
• Product Overview: Human CDK9 full-length ORF (AAH01968, 1 a.a. - 372 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 66.66 kDa
• Protein Length: 372 amino acids
• AA Sequence: MAKQYDSVECPFCDEVSKYEKLAKI GQGTFGEVFKARHRKTGQKVALKKV LMENEKEGFPITALREIKILQLLKH ENVVNLIEICRTKASPYNRCKGSIY LVFDFCEHDLAGLLSNVLVKFTLSE IKRVMQMLLNGLYYIHRNKILHRDM KAANVLITRDGVLKLADFGLARAFS LAKNSQPNRYTNRVVTLWYRPPELL LGERDYGPPIDLWGAGCIMAEMWTR SPIMQGNTEQHQLALISQLCGSITP EVWPNVDNYELYEKLELVKGQKRKV KDRLKAYVRDPYALDLIDKLLVLDP AQRIDSDDALNHDFFWSDPMPSDLK GMLSTHLTSMFEYLAPPRRKGSQIT QQSTNQSRNPATTNQTEFERVF
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CDK9 cyclin-dependent kinase 9 [ Homo sapiens ]
• Official Symbol: CDK9
• Synonyms: CDK9; cyclin-dependent kinase 9; CDC2L4, cyclin dependent kinase 9 (CDC2 related kinase); C 2k; PITALRE; TAK; CDC2-related kinase; cell division protein kinase 9; serine/threonine protein kinase PITALRE; serine/threonine-protein kinase PITALRE; cell division cycle 2-like protein kinase 4; tat-associated kinase complex catalytic subunit; C-2k; CTK1; CDC2L4
• Gene ID: 1025
• mRNA Refseq: NM_001261
• Protein Refseq: NP_001252
• MIM: 603251
• UniProt ID: P50750

Reviews

08/31/2020

Its remarkable quality, versatility, and the manufacturer's commitment to customer satisfaction make it the perfect choice for researchers seeking a premier protein that will undoubtedly enhance their experimental endeavors.

06/26/2019

In addition to its remarkable quality and exceptional technical support, the CDK9 Protein boasts an impressive range of applications.

09/12/2018

The CDK9 Protein has exceeded my expectations by consistently delivering outstanding results and providing exceptional technical support.

Q&As

Is CDK9 targeted only for cancer and antiviral therapies, or are there other applications?

Besides cancer and antiviral therapies, CDK9 is being explored for its role in other diseases, including neurodegenerative disorders.

Can CDK9 inhibitors be used in combination with other cancer treatments?

Yes, combination therapies involving CDK9 inhibitors and other drugs are being investigated to enhance treatment outcomes.

How does the expression of CDK9 vary in different stages of cancer progression?

CDK9 expression tends to increase as cancer progresses, suggesting its potential as a biomarker for disease severity.

How does CDK9 inhibition affect normal cellular functions?

CDK9 inhibitors can impact normal cell functions, leading to potential side effects such as myelosuppression.

Are there ongoing clinical trials involving CDK9 inhibitors?

Yes, several clinical trials are exploring the effectiveness of CDK9 inhibitors in different cancer types.