Recombinant Full Length Human Disintegrin And Metalloproteinase Domain-Containing Protein 12(Adam12) Protein, His-Tagged

• Cat.No.: RFL-35134HF
• Product Overview: Recombinant Full Length Human Disintegrin and metalloproteinase domain-containing protein 12(ADAM12) Protein (O43184) (208-909aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length of Mature Protein (208-909)
• AA Sequence: ETLKATKYVELVIVADNREFQRQGK DLEKVKQRLIEIANHVDKFYRPLNI RIVLVGVEVWNDMDKCSVSQDPFTS LHEFLDWRKMKLLPRKSHDNAQLVS GVYFQGTTIGMAPIMSMCTADQSGG IVMDHSDNPLGAAVTLAHELGHNFG MNHDTLDRGCSCQMAVEKGGCIMNA STGYPFPMVFSSCSRKDLETSLEKG MGVCLFNLPEVRESFGGQKCGNRFV EEGEECDCGEPEECMNRCCNATTCT LKPDAVCAHGLCCEDCQLKPAGTAC RDSSNSCDLPEFCTGASPHCPANVY LHDGHSCQDVDGYCYNGICQTHEQQ CVTLWGPGAKPAPGICFERVNSAGD PYGNCGKVSKSSFAKCEMRDAKCGK IQCQGGASRPVIGTNAVSIETNIPL QQGGRILCRGTHVYLGDDMPDPGLV LAGTKCADGKICLNRQCQNISVFGV HECAMQCHGRGVCNNRKNCHCEAHW APPFCDKFGFGGSTDSGPIRQADNQ GLTIGILVTILCLLAAGFVVYLKRK TLIRLLFTNKKTTIEKLRCVRPSRP PRGFQPCQAHLGHLGKGLMRKPPDS YPPKDNPRRLLQCQNVDISRPLNGL NVPQPQSTQRVLPPLHRAPRAPSVP ARPLPAKPALRQAQGTCKPNPPQKP LPADPLARTTRLTHALARTPGQWET GLRLAPLRPAPQYPHQVPRSTHTAY IK
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: ADAM12
• Synonyms: ADAM12; MLTN; UNQ346/PRO545; Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha
• UniProt ID: O43184

Gene Information

• Gene Name: ADAM12
• Synonyms: ADAM12; MLTN; UNQ346/PRO545; Disintegrin and metalloproteinase domain-containing protein 12; ADAM 12; Meltrin-alpha
• UniProt ID: O43184

Reviews

08/22/2020

The technical staff evaluated my experimental process and results and made many constructive comments

05/28/2019

Protein products are put into experiments with good effect and reliable experimental results

Q&As

In addition to studies related to breast cancer, what other diseases is ADAD12 currently being used to study?

Currently, ADAM12 is also involved in the study of lung cancer and liver cancer.

Does ADAM12 affect Vimentin expression?

ADAM12 upregulates the expression of Vimentin.

Does ADAM12 interact with insulin-like growth factor-binding protein-3 (IGFBP)-3?

ADAM12 interacts with insulin-like growth factor binding protein(IGFBP)-3.

I want to buy ADAM12-related proteins, do you provide other proteins?

We offer myoferlin and Vimentin proteins in addition to ADAM12 proteins.

What protein does ADAM12 hydrolyze?

ADAM12 protein can hydrolyze Delta-like 1、Ephrin-A1, etc.

What are the two conformations of ADAM12?

The two conformations of ADAM are the membrane-penetrating full-length type (ADAM12-L) and the secretory type (ADAM12-S), respectively.