Recombinant Full Length Human DSG1 Protein

• Cat.No.: DSG1-144HF
• Product Overview: Recombinant full length Human Desmoglein 1 with N terminal proprietary tag; Predicted MWt 142.39 kDa inclusive of tag.

Specification

• Description: Desmosomes are cell-cell junctions between epithelial, myocardial and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.
• Source: In Vitro Cell Free System
• Species: Human
• Form: Liquid
• Molecular Mass: 142.390kDa inclusive of tags
• Protein Length: 1049 amino acids
• AA Sequence: MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIK WHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAAN QQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVT PFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMA TFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIR QEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGS DRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQE NTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEI EMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHS IMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGS NDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTG KLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTIN INIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTT STDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLV LGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVE GPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGR EMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNS MRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLI YDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLAD ISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPIS PHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTES YTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGM LEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNV VVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAG VTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGG IGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRIT KYSTVQYSK
• Purity: Proprietary Purification
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles.
• Storage Buffer: pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione.

Gene Information

• Gene Name: DSG1 desmoglein 1 [ Homo sapiens ]
• Official Symbol: DSG1
• Synonyms: DSG1; desmoglein 1; DSG; desmoglein-1; CDHF4
• Gene ID: 1828
• mRNA Refseq: NM_001942
• Protein Refseq: NP_001933
• MIM: 125670
• UniProt ID: Q02413

Reviews

02/22/2023

Its impeccable purity and integrity make it a valuable asset in my research endeavors.

03/02/2022

Their team of experts has been instrumental in resolving any queries or challenges I encountered regarding the application and utilization of the DSG1 protein.

03/22/2021

The DSG1 protein surpasses expectations in terms of quality and is an ideal match for my experimental requirements.

Q&As

How is DSG1 expression regulated in the skin?

Various factors, including cytokines and growth factors, can regulate the expression of DSG1 in skin cells.

Are there any clinical trials focused on DSG1 protein therapies?

Some clinical trials may be exploring DSG1-based therapies for skin disorders, but you should consult clinical trial databases for specific information.

What other medical conditions are associated with DSG1 protein?

DSG1 abnormalities are primarily linked to skin disorders, but some studies suggest potential connections to oral mucosa disorders.

Can DSG1 be used as a biomarker for skin cancer?

While DSG1 is not a direct biomarker for skin cancer, its expression levels may be altered in some skin cancers.

Can DSG1-targeted therapies be used to treat skin conditions?

Research is ongoing, but DSG1-targeted therapies have the potential to treat conditions related to DSG1 deficiencies.