Recombinant Full Length Human ETV6 Protein, C-Flag-tagged

• Cat.No.: ETV6-1247HFL
• Product Overview: Recombinant Full Length Human ETV6 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 52.8 kDa
• AA Sequence: MSETPAQCSIKQERISYTPPESPVP SYASSTPLHVPVPRALRMEEDSIRL PAHLRLQPIYWSRDDVAQWL KWAENEFSLRPIDSNTFEMNGKALL LLTKEDFRYRSPHSGDVLYELLQHI LKQRKPRILFSPFFHPGNSI HTQPEVILHQNHEEDNCVQRTPRPS VDNVHHNPPTIELLHRSRSPITTNH RPSPDPEQRPLRSPLDNMIR RLSPAERAQGPRPHQENNHQESYPL SVSPMENNHCPASSESHPKPSSPRQ ESTRVIQLMPSPIMHPLILN PRHSVDFKQSRLSEDGLHREGKPIN LSHREDLAYMNHIMVSVSPPEEHAM PIGRIADCRLLWDYVYQLLS DSRYENFIRWEDKESKIFRIVDPNG LARLWGNHKNRTNMTYEKMSRALRH YYKLNIIRKEPGQRLLFRFM
  KTPDEIMSGRTDRLEHLESQELDEQ IYQEDECSGPTRTRPLEQKLISEED LAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Dorso-ventral axis formation

Gene Information

• Gene Name: ETV6 ETS variant transcription factor 6 [ Homo sapiens (human) ]
• Official Symbol: ETV6
• Synonyms: TEL; THC5; TEL/ABL
• Gene ID: 2120
• mRNA Refseq: NM_001987.5
• Protein Refseq: NP_001978.1
• MIM: 600618
• UniProt ID: P41212