Description : |
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. |
Source : |
In Vitro Cell Free System |
Species : |
Human |
Form : |
Liquid |
Molecular Mass : |
54.490kDa inclusive of tags |
Protein Length : |
258 amino acids |
AA Sequence : |
MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYVYQG RQECYAFNGTQRFLERYIYNREEYARFDSDVGEFRAVT ELGRPAAEYWNSQKDILEEKRAVPDRVCRHNYELDEAVTL QRRVQPKVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQV RWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGD VYICQVEHTSLDSPVTVEWKAQSDSAQSKTLTGAGGFV LGLIICGVGIFMHRRSKKVQRGSA |
Purity : |
Proprietary Purification |
Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80 centigrade. Avoid freeze / thaw cycles. |
Storage Buffer : |
pH: 8.00. Constituents:0.79% Tris HCl, 0.31% Glutathione. |