HLA-E
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Official Full Name
major histocompatibility complex, class I, E
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Overview
HLA-E belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-E binds a restricted subset of peptides derived from the leader peptides of other class I molecules. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. -
Synonyms
HLA-E; major histocompatibility complex, class I, E; HLA class I histocompatibility antigen, alpha chain E; MHC HLA-E alpha-1; lymphocyte antigen; MHC HLA-E alpha-2.1; MHC class I antigen E; HLA class I histocompatibility antigen, E alpha chain; MHC; QA1; EA1.2; EA2.1; HLA-6.2; DKFZp686P19218;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- SUMO
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HLA-E-1746H | Recombinant Human HLA-E protein, His-tagged | E.coli | His | Gly22~Leu358 | |
Human | HLA-E-4847H | Recombinant Human HLA-E Protein, GST-tagged | Wheat Germ | GST | ||
Human | HLA-E-800HCL | Recombinant Human HLA-E cell lysate | N/A | |||
Human | HLA-E-039H | Recombinant Human HLA-E protein, His-Avi-tagged, Biotinylated | HEK293 | His-Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. | |
Human | HLA-E-038H | Recombinant Human HLA-E protein, His-Avi-tagged | HEK293 | His-Avi | It contains Gly25-Ile305(HLA-E),Ile21-Met119(B2M) and VMAPRTLVL peptide. | |
Human | HLA-E-2276H | Recombinant Human HLA-E protein, His&Myc-tagged | Insect Cell | His&Myc | 22-305aa | |
Human | HLA-E-1076H | Recombinant Human HLA-E Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | HLA-E-3602HF | Recombinant Full Length Human HLA-E Protein, GST-tagged | In Vitro Cell Free System | GST | 358 amino acids | |
Human | HLA-E-1749H | Recombinant Human HLA-E Protein, MYC/DDK-tagged | HEK293T | Myc/DDK | ||
Human | HLA-E-3399H | Recombinant Human HLA-E protein, His-tagged | E.coli | His | 23-303 aa | |
Human | HLA-E-1076H-B | Recombinant Human HLA-E Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | HLA-E-268HFL | Recombinant Full Length Human HLA-E Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | HLA-E-3872H | Recombinant Human HLA-E protein, His-SUMO-tagged | E.coli | His-SUMO | 22-305aa | |
Human | HLA-E-040HP | Recombinant Human HLA-E complex Protein (tetramer), His-Avi-tagged, PE-Labeled | HEK293 | His-Avi | Gly25-Ile305(HLA-E*01:03),Ile21-Met119(B2M) and VMAPRTLVL peptide |
- Involved Pathway
- Protein Function
- Interacting Protein
- HLA-E Related Articles
- HLA-E Related Research Area
HLA-E involved in several pathways and played different roles in them. We selected most pathways HLA-E participated on our site, such as Endocytosis, Phagosome, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with HLA-E were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | VPS37C;SH3GL3A;CCR5;SH3GLB1A;IST1;PRKCI;CXCR1;HLA-E;ARPC5LB |
Phagosome | TUBA1C;MHC2DAB;ITGB5;ACTB;HLA-E;TUBB;ATP6V1D;CLEC7A;TUBA3A |
Cell adhesion molecules (CAMs) | TIGIT;CD22;HLA-DPA1;ITGA6;PDCD1LG2;NLGN4X;ITGB2;CLDN5B;CD40 |
Antigen processing and presentation | PDIA3;LGMN;KLRC3;CD8B1;KLRC2;TNF;HLA-DOA;CANX;KIR2DS5 |
Natural killer cell mediated cytotoxicity | Fasl;NFATC2;RAF1;ICAM1;SH2D1A;SYK;RAET1E;FCER1G;NCR2 |
Type I diabetes mellitus | HLA-DRB5;Fasl;HLA-DMA;CD28;HLA-DOB;LTA;CD80;IL1A;HLA-DQB1 |
HTLV-I infection | PDGFB;TGFBR1;WNT10B;XBP1;Adcy4;WNT8A;MAP3K1;WNT9A;DVL3 |
Herpes simplex infection | CASP3A;TAF6;POU2F3;IL12A;CUL1A;EIF2AK2;CDC34;ARNTL1A;HLA-E |
Epstein-Barr virus infection | ENTPD3;IL10RB;SNW1;POLR2G;RELA;HLA-DPA1;TRADD;PRKACG;GSK3B |
Viral carcinogenesis | HIST1H4H;LYN;TRAF3;HIST1H2BP;HIST1H2BH;HIST1H2BM;TBPL1;SCIN;SP100 |
Autoi | HLA-DRB3;HLA-DRA;HLA-G;H2-Q10;IL5;IFNA1;GZMB;IFNA13;IFNA10 |
ne thyroid disease | IFNA14;CD80;HLA-F;IFNA21;IFNA17;HLA-G;Fasl;HLA-DRA;PRF1 |
Allograft rejection | HLA-DRB5;HLA-DRA;HLA-DMB;CD40;IL12A;FASLG;HLA-F;Il2;H2-AB1 |
Graft-versus-host disease | IL6;HLA-F;HLA-DOA;KLRC1;IL1A;H2-AA;HLA-DRB5;H2-Q10;HLA-DQA1 |
Viral myocarditis | HLA-DRB1;SGCD;SGCA;HLA-A;ACTG1;CCND1;HLA-DQB1;CYCS;HLA-DQA1 |
HLA-E has several biochemical functions, for example, MHC class I protein binding, beta-2-microglobulin binding, natural killer cell lectin-like receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HLA-E itself. We selected most functions HLA-E had, and list some proteins which have the same functions with HLA-E. You can find most of the proteins on our site.
Function | Related Protein |
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MHC class I protein binding | TUBB;HLA-E;LILRB2;CD244;ATP5A1;CD8A;TUBB4B;BCAP31;TAP1 |
beta-2-microglobulin binding | H2-Q10;CD1C;CD1d1;HLA-A;CD1E;CD1A;HLA-E;CD1B;FCGRT |
natural killer cell lectin-like receptor binding | RAET1L;Raet1a;MICA;ULBP2;ULBP3;RAET1G;RAET1E;RAET1D;Mill2 |
peptide antigen binding | HLA-DRB3;HLA-A;HLA-DRB5;H2-Q10;MHC1ZHA;H2-AB1;MHC1UJA;HLA-DQA1;HLA-DPB1 |
receptor binding | HFE2;ICOSLG;HSPA1A;VTCN1;PKD2;Fert2;BMP3;PANX1;PPY |
HLA-E has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HLA-E here. Most of them are supplied by our site. Hope this information will be useful for your research of HLA-E.
YPMT1.25Ac; TRAPPC2; fusA; lldD1; q5ni35_fratt; q7chg5_yerpe; proW; q7ckk6_yerpe; deoB; ptsG; y2173_bacan; q81wx2_bacan; dacF; q81z87_bacan; q8cl08_yerpe; sfcA2; leuB; PPP1R16A
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