Recombinant Full Length Human NDRG1 Protein, C-Flag-tagged

• Cat.No.: NDRG1-1632HFL
• Product Overview: Recombinant Full Length Human NDRG1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 42.7 kDa
• AA Sequence: MSREMQDVDLAEVKPLVEKGETITG LLQEFDVQEQDIETLHGSVHVTLCG TPKGNRPVILTYHDIGMNHK TCYNPLFNYEDMQEITQHFAVCHVD APGQQDGAASFPAGYMYPSMDQLAE MLPGVLQQFGLKSIIGMGTG AGAYILTRFALNNPEMVEGLVLINV NPCAEGWMDWAASKISGWTQALPDM VVSHLFGKEEMQSNVEVVHT YRQHIVNDMNPGNLHLFINAYNSRR DLEIERPMPGTHTVTLQCPALLVVG DSSPAVDAVVECNSKLDPTK TTLLKMADCGGLPQISQPAKLAEAF KYFVQGMGYMPSASMTRLMRSRTAS GSSVTSLDGTRSRSHTSEGT
  RSRSHTSEGTRSRSHTSEGAHLDIT PNSGAAGNSAGPKSMEVSCTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.

Gene Information

• Gene Name: NDRG1 N-myc downstream regulated 1 [ Homo sapiens (human) ]
• Official Symbol: NDRG1
• Synonyms: GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1
• Gene ID: 10397
• mRNA Refseq: NM_006096.4
• Protein Refseq: NP_006087.2
• MIM: 605262
• UniProt ID: Q92597

Reviews

11/22/2020

Their expertise and assistance have been invaluable in troubleshooting and providing insightful solutions, greatly enhancing the progress of my experiments.

08/26/2020

They have proven to be a timely and reliable resource, readily addressing any concerns or challenges that arise during my research.

06/05/2018

The NDRG1 Protein's superior stability and functional performance render it an indispensable tool for a wide range of scientific investigations.

Q&As

Can NDRG1 be targeted for personalized medicine approaches?

Yes, understanding the individual's NDRG1 expression profile may enable personalized treatment strategies, especially in cancer therapy.

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there therapeutic implications for modulating NDRG1 expression in cancer treatment?

Are there clinical trials investigating the use of NDRG1-related therapies?

Yes, there are ongoing clinical trials exploring the safety and efficacy of NDRG1-targeted therapies in various diseases, reflecting the growing interest in its clinical applications.

How does NDRG1 contribute to cellular stress response?

NDRG1 is involved in cellular responses to various stresses, including oxidative stress and DNA damage, playing a role in maintaining cellular homeostasis.

How does NDRG1 affect cardiovascular health?

NDRG1 is involved in processes related to cardiac hypertrophy and response to ischemic stress, making it relevant to cardiovascular diseases.