Recombinant Full Length Human NEUROD1 Protein, C-Flag-tagged

• Cat.No.: NEUROD1-389HFL
• Product Overview: Recombinant Full Length Human NEUROD1 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 39.7 kDa
• AA Sequence: MTKSYSESGLMGEPQPQGPPSWTDE CLSSQDEEHEADKKEDDLEAMNAEE DSLRNGGEEEDEDEDLEEEE EEEEEDDDQKPKRRGPKKKKMTKAR LERFKLRRMKANARERNRMHGLNAA LDNLRKVVPCYSKTQKLSKI ETLRLAKNYIWALSEILRSGKSPDL VSFVQTLCKGLSQPTTNLVAGCLQL NPRTFLPEQNQDMPPHLPTA SASFPVHPYSYQSPGLPSPPYGTMD SSHVFHVKPPPHAYSAALEPFFESP LTDCTSPSFDGPLSPPLSIN GNFSFKHEPSAEFEKNYAFTMHYPA ATLAGAQSHGSIFSGTAAPRCEIPI DNIMSFDSHSHHERVMSAQL
  NAIFHDTRTRPLEQKLISEEDLAAN DILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Adult stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transcription Factors
• Protein Pathways: Maturity onset diabetes of the young

Gene Information

• Gene Name: NEUROD1 neuronal differentiation 1 [ Homo sapiens (human) ]
• Official Symbol: NEUROD1
• Synonyms: T2D; BETA2; BHF-1; MODY6; NEUROD; bHLHa3
• Gene ID: 4760
• mRNA Refseq: NM_002500.5
• Protein Refseq: NP_002491.3
• MIM: 601724
• UniProt ID: Q13562