Recombinant Full Length Human Putative Atp-Binding Cassette Sub-Family C Member 13(Abcc13) Protein, His-Tagged

• Cat.No.: RFL35687HF
• Product Overview: Recombinant Full Length Human Putative ATP-binding cassette sub-family C member 13(ABCC13) Protein (Q9NSE7) (1-274aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Homo sapiens (Human)
• Tag: His
• Form: Lyophilized powder
• Protein Length: Full Length (1-274)
• AA Sequence: MLSSTQNAGGSYQRVRGALDTQKCS PEKSASFFSKVTYSWFSRVITLGYK RPLEREDLFE LKESDSFCTACPIFEKQWRKEVLRN QERQKVKVSCYKEAHIKKPSLLYAL WNTFKSILIQ VALFKVFADILSFTSPLIMKQIIIF CEHSSDFGWNGYGYAVALLVVVFLQ TLILQQYQRF NMLTSAKVKTAVNGLIYKKALLLSN VSRQKFSTGEIINLMSATHGLDSKP QSPLVCPFSN PNGRISPLARAGSSSVSRGGSPCVC YTNKCFSCN
• Purity: Greater than 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: ABCC13
• UniProt ID: Q9NSE7

Gene Information

• Gene Name: ABCC13
• UniProt ID: Q9NSE7

Reviews

08/07/2019

The strip is clear and of high quality

03/09/2018

Proper purity

08/05/2017

Fast transportation

Q&As

How long does it take for the product to be shipped?

It depends on your location, we usually use FedEx to send our products.

Which proteins does ABCC13 interact with in Globin Switching

Including hist1h2bl, al133243.2, trim58, abcc13, bpgm, and fam210b were identified in the coexpression network

How ABCC13 works with immune cells?

Except for ABCC12/13, the ABCCs were significantly associated with B cell, CD8+ T cell, CD4+ T cell, macrophage, neutrophil, and dendritic cell infiltration

what's the stucture of ABCC13

The ABCC13 gene spans approximately 70kb on human chromosome 21q11.2 and consists of 14 exons. The open reading frame of the ABCC13 cDNA encodes a peptide consisting of 325 amino acid residues. The amino acid sequence corresponding to putative membrane-spanning domains was remarkably similar to ABCC1, ABCC2, ABCC3, and ABCC6.

Could ABCC13 be the biomarker for lung adenocarcinoma?

While some studies have investigated the potential of ABCC13 as a biomarker for lung adenocarcinoma, further research is needed to determine its clinical utility and to confirm its specificity and sensitivity as a diagnostic and prognostic marker for this type of cancer.

Where does ABCC13 express more in the human body

The ABCC13 gene was expressed in the fetal liver at the highest level among the organs studied. While ABCC13 was expressed in the bone marrow, its expression in peripheral blood leukocytes of adult humans was much lower and no detectable levels were observed in differentiated hematopoietic cells.

Why does ABCC13 belong to MRP class?

ABCC13 shares a similar structure to other MRP transporters, with three TMDs and two NBDs. Although its function is not yet fully characterized, studies suggest that it may be involved in the transport of glutathione and other conjugates.

Does ABCC13 have multidrug resistance function?

MRP10/ABCC13 is clearly a pseudo-gene which encodes a truncated protein that is highly expressed in fetal human liver with the highest similarity to MRP2/ABCC2 but without transporting activity.

Is ABCC13 related to colon cancer?

There is no clear evidence at present that ABCC13 is directly linked to colon cancer.

Where is ABCC13 located on the chromosome

21q11.2-q21.1

What's the role of ABCC13 in wheat?

Study data demonstrate that wheat ABCC13 is functionally important for grain development and plays an important role during detoxification of heavy metals.