Recombinant Full Length Human RELB Protein, C-Flag-tagged

• Cat.No.: RELB-1446HFL
• Product Overview: Recombinant Full Length Human RELB Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and protein kinase binding activity. Involved in lymphocyte differentiation and negative regulation of interferon-beta production. Located in cytosol and nucleoplasm. Part of chromatin; nucleus; and transcription repressor complex. Colocalizes with centrosome. Implicated in breast cancer and immunodeficiency 53. Biomarker of breast cancer and transitional cell carcinoma.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 62 kDa
• AA Sequence: MLRSGPASGPSVPTGRAMPSRRVAR PPAAPELGALGSPDLSSLSLAVSRS TDELEIIDEYIKENGFGLDG GQPGPGEGLPRLVSRGAASLSTVTL GPVAPPATPPPWGCPLGRLVSPAPG PGPQPHLVITEQPKQRGMRF RYECEGRSAGSILGESSTEASKTLP AIELRDCGGLREVEVTACLVWKDWP HRVHPHSLVGKDCTDGICRV RLRPHVSPRHSFNNLGIQCVRKKEI EAAIERKIQLGIDPYNAGSLKNHQE VDMNVVRICFQASYRDQQGQ MRRMDPVLSEPVYDKKSTNTSELRI CRINKESGPCTGGEELYLLCDKVQK EDISVVFSRASWEGRADFSQ ADVHRQIAIVFKTPPYEDLEIVEPV TVNVFLQRLTDGVCSEPLPFTYLPR DHDSYGVDKKRKRGMPDVLG ELNSSDPHGIESKRRKKKPAILDHF LPNHGSGPFLPPSALLPDPDFFSGT VSLPGLEPPGGPDLLDDGFA YDPTAPTLFTMLDLLPPAPPHASAV VCSGGAGAVVGETPGPEPLTLDSYQ APGPGDGGTASLVGSNMFPN
  HYREAAFGGGLLSPGPEATTRTRPL EQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: MAPK signaling pathway

Gene Information

• Gene Name: RELB RELB proto-oncogene, NF-kB subunit [ Homo sapiens (human) ]
• Official Symbol: RELB
• Synonyms: IREL; I-REL; IMD53; REL-B
• Gene ID: 5971
• mRNA Refseq: NM_006509.4
• Protein Refseq: NP_006500.2
• MIM: 604758
• UniProt ID: Q01201