Recombinant Full Length Human SOD3 Protein, C-Flag-tagged

• Cat.No.: SOD3-586HFL
• Product Overview: Recombinant Full Length Human SOD3 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the conversion of superoxide radicals into hydrogen peroxide and oxygen, which may protect the brain, lungs, and other tissues from oxidative stress. Proteolytic processing of the encoded protein results in the formation of two distinct homotetramers that differ in their ability to interact with the extracellular matrix (ECM). Homotetramers consisting of the intact protein, or type C subunit, exhibit high affinity for heparin and are anchored to the ECM. Homotetramers consisting of a proteolytically cleaved form of the protein, or type A subunit, exhibit low affinity for heparin and do not interact with the ECM. A mutation in this gene may be associated with increased heart disease risk.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 24.1 kDa
• AA Sequence: MLALLCSCLLLAAGASDAWTGEDSA EPNSDSAEWIRDMYAKVTEIWQEVM QRRDDDGTLHAACQVQPSAT LDAAQPRVTGVVLFRQLAPRAKLDA FFALEGFPTEPNSSSRAIHVHQFGD LSQGCESTGPHYNPLAVPHP QHPGDFGNFAVRDGSLWRYRAGLAA SLAGPHSIVGRAVVVHAGEDDLGRG GNQASVENGNAGRRLACCVV
  GVCGPGLWERQAREHSERKKRRRES ECKAATRTRPLEQKLISEEDLAAND ILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein

Gene Information

• Gene Name: SOD3 superoxide dismutase 3 [ Homo sapiens (human) ]
• Official Symbol: SOD3
• Synonyms: EC-SOD
• Gene ID: 6649
• mRNA Refseq: NM_003102.4
• Protein Refseq: NP_003093.2
• MIM: 185490
• UniProt ID: P08294

Reviews

02/19/2023

Trusted for results accuracy. A research necessity.

06/22/2017

Efficient and dependable. Accelerates our research progress.

06/12/2017

Enhances research credibility. Consistent and trustworthy.

Q&As

What potential therapeutic applications arise from targeting SOD3 in oxidative stress-related conditions?

Enhancing SOD3 activity could be a therapeutic strategy in treating oxidative stress-related diseases.

How do genetic variations in SOD3 affect its antioxidant function?

Genetic mutations in SOD3 can impair its ability to scavenge free radicals, affecting its protective role.

How does SOD3 contribute to cellular protection against free radicals?

It protects cells from oxidative damage by converting free radicals to less harmful substances.

What is the impact of altered SOD3 activity on aging and age-related diseases?

Altered SOD3 activity is linked with accelerated aging and the development of age-related diseases.

How does SOD3 interact with other cellular antioxidants?

SOD3 works alongside other antioxidants, contributing to the overall oxidative defense system.

What is the primary role of SOD3 in oxidative stress management?

SOD3, a type of superoxide dismutase, is crucial for neutralizing superoxide radicals, reducing oxidative stress.

What role does SOD3 play in cardiovascular health?

SOD3 is important for cardiovascular health, preventing oxidative damage in blood vessels.