Recombinant Full Length Mouse Atp-Binding Cassette Sub-Family G Member 3(Abcg3) Protein, His-Tagged
Cat.No. : | RFL17938MF |
Product Overview : | Recombinant Full Length Mouse ATP-binding cassette sub-family G member 3(Abcg3) Protein (Q99P81) (1-650aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Mus musculus (Mouse) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-650) |
AA Sequence : | MASNNDPTVISMIERHLCDLPETNT SDLKTLTEEAVLSFHNISYQETVQS GFPLRKKAYV IERLSNISGIMKPGLNAIMGPQDGS RSLLLDVLAARRDPRGLSGDILING KPRPANFKCT SGYVPQNDVVLGTVTVRDNLEFSAA LRLPVTITRDEKRRRINEVLELLHL NKEQNIKPRS KELRKRTSIAMELVTEHPILFLDDP TTGLDLRTTTDVILVLRRMSKKGRT IIFSINQPQY SIFKFFDSLTLVASGKVMFHGPAQD ALEYFRSAGYNYESHNNPADFFLDV INGGFSNILD TEEDGHEDDKYEELFERQYQVTGKL ANMYAQSPLYSETRAILDQLLGEQK LERSSAVETT CVTPFCHQLKWIICQSFKNFKGFPW VTVIQAIITVILATAVGTAFRVLKN DCIEVQMRAG LLYLLTIFQCITSVSAGELFVIDRV RFLHEHTSGYYRVSSYFFGKLLAEL IPRRLLPSTV FSLITYVIAGVKMSMKCFFTMICTI MVLAYSASSLPLSIGAGENAVAVPT LLVTIYFVFM LFFSGLSLYSGSFLPKLSWIQYFSI PHYGFRALLHNEFLGQNFCPEHNTE EVSRCHNYVI CTGEEFLMIQGIDLSSWGFWENHLA LVCTMIILLTITYVQLLQVKNIRNF |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Abcg3 |
Synonyms : | Abcg3; ATP-binding cassette sub-family G member 3 |
UniProt ID : | Q99P81 |
Gene Name : | Abcg3 |
Synonyms : | Abcg3; ATP-binding cassette sub-family G member 3 |
UniProt ID : | Q99P81 |
Products Types
◆ Recombinant Protein | ||
ABCG3-208M | Recombinant Mouse ABCG3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ABCG3-1116M | Recombinant Mouse ABCG3 Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (21)
Ask a questionABCG3 deficiency or overexpression can have physiological consequences, such as altered sterol levels, disturbed lipid metabolism, or increased susceptibility to certain diseases.
Yes, Abcg3 is unique among ABC genes in not having several highly conserved residues in the A and C domains of the NBF.
ABCG3 interacts with various cellular components and pathways involved in lipid metabolism, such as ATP-binding cassette transporters, nuclear receptors, and lipid synthesis enzymes.
Abcg3 may not bind ATP and would,ATP and would, therefore, have to dimerize with another subunit to form a functional trans- porter.
ABCG3 activity is regulated through various mechanisms, including transcriptional control, post-transcriptional modifications, and protein-protein interactions.
Currently, there are no specific pharmacological inhibitors or activators of ABCG3 reported in the literature.
The protein may function in lymphocytes. It is possible that the gene participates in the transport of specific peptides or hydrophobic compounds from these cells.
The ABCG3 gene was initially identified and characterized through genetic and molecular studies, including gene expression profiling, sequencing, and functional assays.
ABCG3 expression can vary during development or in different life stages. For example, its expression may be higher during embryonic development or in specific tissues during adulthood.
ABCG3 has the potential to be targeted for therapeutic interventions or drug development, particularly in conditions related to sterol metabolism disorders or cholesterol-related diseases.
ABCG3 expression can be influenced by genetic factors, including single nucleotide polymorphisms, as well as epigenetic modifications, such as DNA methylation or histone modifications.
For Abcg3, the highest levels of expression were found in thymus and spleen.
The Abcg3 gene has 16 exons, including one 5 non-coding exon.
ABCG3 is known to transport sterols, such as plant sterols or cholesterol, across cell membranes. It may also transport other lipids or lipid-related molecules.
Mutations in the ABCG3 gene can lead to sitosterolemia, a rare autosomal recessive disorder characterized by the accumulation of plant sterols in the body.
Sitosterolemia is the primary genetic disorder linked to ABCG3 mutations, characterized by the impaired excretion of plant sterols and increased absorption from the diet.
Certain genetic polymorphisms in ABCG3 have been associated with altered cholesterol levels, increased risk of atherosclerosis, or other lipid-related disorders.
ABCG3 shares functional similarities with other ABC transporters, particularly ABCG1 and ABCG2, in terms of their involvement in cellular lipid transport and homeostasis.
ABCG3 is primarily localized to the cell membrane, specifically the plasma membrane or the membranes of specific organelles, depending on the cell type.
Customer Reviews (5)
Write a reviewIt enabled versatile experimentation.
The protein product's high bioactivity ensured its effectiveness in functional assays, providing accurate and meaningful results.
I appreciated the product's consistent performance in my experiments, as it exhibited minimal batch-to-batch variability, ensuring reliable and reproducible results
The protein product's high level of bioavailability made it suitable for a wide range of applications.
The protein product's low background noise in my experiments reflected its purity and minimized interference from impurities.
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