ABCG1
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Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 1
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Overview
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. -
Synonyms
ABCG1; ATP-binding cassette, sub-family G (WHITE), member 1; ATP-binding cassette sub-family G member 1; ABC8; ATP binding cassette transporter 8; ABC transporter 8; homolog of Drosophila white; ATP-binding cassette transporter 8; ATP-binding cassette transporter member 1 of subfamily G; white protein homolog (ATP-binding cassette transporter 8); WHITE1; MGC34313;
- Recombinant Proteins
- Arabidopsis thaliana (Mouse-ear cress)
- Dictyostelium discoideum (Slime mold)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His|Myc
- Myc
- DDK
- MYC
- Myc|DDK
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- ABCG1 Related Articles
ABCG1 involved in several pathways and played different roles in them. We selected most pathways ABCG1 participated on our site, such as ABC transporters, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ABC transporters | SUR2A;ABCG2;ABCB7;ABCB6A;ABCD3A;ABCA3;ABCA1B;ABCB11;ABCA8 |
ABCG1 has several biochemical functions, for example, ADP binding, ATP binding, cholesterol binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCG1 itself. We selected most functions ABCG1 had, and list some proteins which have the same functions with ABCG1. You can find most of the proteins on our site.
Function | Related Protein |
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ADP binding | P2RY1;LONP1;PKM;ADCK3;CYB5R3;TAP1;CHORDC1;ATP1A1;VCP |
ATP binding | RAF1;SMC5;PI4KB;RFC5;NAV2;SPHK2;ATP4A;AASDH;MAP3K2 |
cholesterol binding | OSBPL2;OSBPL7;OSBPL8;TSPO;APOA1A;APOA1;SCP2;APOA4B.2;APOA2 |
cholesterol transporter activity | APOA4B.1;APOA4A;APOA4B.2;APOE;APOA1;CETP;APOEB;ABCA1B;APOA4 |
glycoprotein transporter activity | VLDLR;ABCG1 |
phospholipid binding | APOA5;APOC3;ABCG1;OSBPL1A;APOE;SHC1;F3;NBEA;VAMP2 |
phospholipid transporter activity | MFSD2AA;ABCA4;ABCG1;MFSD2A;CETP;OSBPL8;ABCA1;ATP8B5;MTTP |
protein binding | KCNJ4;TLE3;DDC;CRK;FAM200A;HPN;SLC9A3;BMPR1B;SREK1 |
protein dimerization activity | SOHLH2;BETA3;EBF2;CREB3;AIFM1;TFE3B;MYCA;ZBED4;MAX |
protein heterodimerization activity | GTF2A2;CD3D;RALGAPA1;DRD2;HIST1H2BA;TIMELESS;H3F3A;ATF2;ADIPOR2 |
protein homodimerization activity | SNRPC;IDE;SLC26A5;LRRK2;XBP1;TESC;UGT1A6A;DROSHA;BNIP3L |
sterol-transporting ATPase activity | ABCG1;ABCG4B |
toxin transporter activity | SLC17A3;SLC7A8;ABCG1;SLC22A3;SLC22A2;LRP6 |
ABCG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCG1.
- Q&As
- Reviews
Q&As (20)
Ask a questionABCG1 contributes to the prevention of atherosclerosis.ABCG1 helps reduce the formation of foam cells, which are a key component of atherosclerotic plaques. By reducing foam cell formation and lipid deposition, ABCG1 can help protect against the development and progression of atherosclerosis.
ABCG1 expression is regulated at the transcriptional level in response to changes in cellular cholesterol levels. Sterol regulatory element-binding proteins (SREBPs) are key transcription factors involved in this regulation. When cellular cholesterol levels are low, SREBPs are activated, leading to the upregulation of ABCG1 expression.
ABCG1 has been linked to cellular processes like cell proliferation, apoptosis, and autophagy, indicating its involvement in broader cellular functions.
ABCG1 is known to play a role in immune cells, particularly macrophages. It contributes to cholesterol homeostasis in macrophages, which is crucial for their proper function in the immune response.
Several signaling pathways and protein-protein interactions are involved in the regulation of ABCG1 activity and intracellular trafficking. The activation of nuclear receptors, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), can upregulate ABCG1 expression.
ABCG1 functions as a transporter protein that facilitates the efflux of cellular lipids, particularly cholesterol and phospholipids, to maintain lipid balance. By promoting the efflux of excess cholesterol, ABCG1 helps prevent cholesterol accumulation and the formation of lipid droplets within cells.
Dysregulation of ABCG1 in immune cells can affect inflammatory processes and the development of diseases such as atherosclerosis.
Yes, there are known genetic variations and polymorphisms in the ABCG1 gene that have been associated with altered lipid profiles and an increased risk of cardiovascular disease.
The specific lipid substrates transported by ABCG1 are primarily cholesterol and phospholipids. ABCG1 promotes the efflux of these lipids from cells to extracellular acceptors, such as high-density lipoprotein (HDL) particles
ABCG1 (ATP-binding cassette subfamily G member 1) is a member of the ATP-binding cassette (ABC) transporter superfamily.
The expression of ABCG1 can vary among different cell types and tissues. For example,ABCG1 is highly expressed in macrophages while low in liver.
It plays a crucial role in cellular lipid homeostasis by mediating the efflux of lipids, primarily cholesterol and phospholipids, from cells. ABCG1 is involved in maintaining cholesterol balance and regulating lipid metabolism.
These include synthetic agonists for nuclear receptors, such as liver X receptors (LXRs) and peroxisome proliferator-activated receptors (PPARs), which can enhance ABCG1 expression.
ABCG1 is predominantly found in the plasma membrane but can also be localized to intracellular compartments, such as endosomes and the Golgi apparatus. Its subcellular distribution may vary depending on the cell type and physiological conditions.
Yes, ABCG1 plays a role in foam cell formation and the pathogenesis of atherosclerotic plaques. Foam cells are formed when macrophages in arterial walls take up excessive cholesterol and become overloaded with lipids.
Phosphorylation of specific serine residues has been shown to modulate ABCG1 function and its interaction with other proteins
ABCG1 expression is regulated by various factors, including sterol regulatory element-binding proteins (SREBPs), liver X receptors (LXRs), and peroxisome proliferator-activated receptors (PPARs
The distribution and activity of ABCG1 can be influenced by cell-specific regulatory factors and physiological conditions.
ABCG1 can interact with other lipid transporters, membrane proteins, and signaling molecules to facilitate lipid efflux and maintain cellular homeostasis.
The full name of ABCG1 is ATP-binding cassette subfamily G member 1.
Customer Reviews (5)
Write a reviewI have been consistently impressed by the reliability and consistency of the protein product
It effectively interacting with other molecules as expected.
The protein product was easy to work with.
The protein product displayed excellent stability.
Their experts offering valuable insights and troubleshooting advice for my experiments.
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