Recombinant Full Length Mouse E3 Ubiquitin-Protein Ligase Amfr(Amfr) Protein, His-Tagged
Cat.No. : | RFL32124MF |
Product Overview : | Recombinant Full Length Mouse E3 ubiquitin-protein ligase AMFR(Amfr) Protein (Q9R049) (1-643aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Mus musculus (Mouse) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-643) |
AA Sequence : | MPLLFLERFPWPSLRTYTGLSGLAL LGTIVSAYRALSQPEDGSGEPEPLT APLQPEALAP ARLTAGGPRARDVAQYLLSDSLFVW VLVNTACCVLMLVAKLIQCIVFGPL RVSERQHLKD KFWNFIFYKFIFIFGVLNVQTVEEV VMWCLWFAGLVFLHLMVQLCKDRFE YLSFSPTTPM SSHGRVLSLLIAMLLSCCGLAVVCC VTGYTHGMHTLAFMAAESLLVTVRT AHVILRYVIH LWDLNHEGTWEGKGTYVYYTDFVME LALLSLDLMHHIHMLLFGNIWLSMA SLVIFMQLRY LFHEVQRRIRRHKNYLRVVGNMEAR FAVATPEELAVNNDDCAICWDSMQA ARKLPCGHLF HNSCLRSWLEQDTSCPTCRMSLNIA DGSRAREDHQGENLDENLVPVAAAE GRPRLNQHNH FFHFDGSRIASWLPSFSVEVMHTTN ILGITQASNSQLNAMAHQIQEMFPQ VPYHLVLQDL QMTRSVEITTDNILEGRIQVPFPTQ RSDSLRPALNSPVERPSPDLEEGEA SVQTERVPLD LSPRLEETLDFSEVELEPIEVEDFE ARGSRFSKSADERQRMLVQRKDDLL QQARKRFLNK SSEDDGASERLLPSEGTSSDPVTLR RRMLAAAAERRLQRQRTT |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Amfr |
Synonyms : | Amfr; E3 ubiquitin-protein ligase AMFR; Autocrine motility factor receptor; AMF receptor; RING-type E3 ubiquitin transferase AMFR |
UniProt ID : | Q9R049 |
Gene Name : | Amfr |
Synonyms : | Amfr; E3 ubiquitin-protein ligase AMFR; Autocrine motility factor receptor; AMF receptor; RING-type E3 ubiquitin transferase AMFR |
UniProt ID : | Q9R049 |
Products Types
◆ Recombinant Protein | ||
Amfr-515M | Recombinant Mouse Amfr Protein, His-tagged | +Inquiry |
AMFR-514H | Recombinant Human AMFR Protein, His-tagged | +Inquiry |
AMFR-3783H | Recombinant Human AMFR, GST-tagged | +Inquiry |
AMFR-12379Z | Recombinant Zebrafish AMFR | +Inquiry |
AMFR-520H | Recombinant Human AMFR protein, GST-tagged | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionAMFR plays a crucial role in protein turnover and degradation pathways, promoting the degradation of misfolded or unwanted proteins through the ubiquitin-proteasome system and autophagy.
AMFR interacts with various cellular proteins involved in protein quality control, including chaperones, ubiquitin ligases, and components of the ERAD machinery.
Depletion or overexpression of AMFR can disrupt cellular proteostasis, leading to the accumulation of misfolded proteins and impaired cell viability.
AMFR is responsible for recognizing and delivering misfolded or aggregated proteins for degradation, thereby preventing their accumulation and proteotoxicity.
AMFR activity and stability can be regulated by post-translational modifications, such as ubiquitination or phosphorylation, and by signaling pathways, including the unfolded protein response (UPR) pathway.
AMFR participates in the endoplasmic reticulum-associated degradation (ERAD) pathway, which targets misfolded proteins in the ER for proteasomal degradation.
AMFR protein is predominantly localized to the endoplasmic reticulum (ER), with a distribution pattern that includes ER membranes and ER-associated structures.
AMFR expression can be upregulated in response to cellular stress, such as oxidative stress or endoplasmic reticulum (ER) stress.
Targeting AMFR holds therapeutic potential for protein aggregation diseases and neurodegenerative disorders by promoting protein clearance and reducing protein aggregates' toxicity.
AMFR may have a role in coordinating cellular responses to DNA damage or genotoxic stress, potentially through its involvement in protein quality control mechanisms.
Customer Reviews (3)
Write a reviewAccurate measurement of protein turnover rates.
Reduced non-specific binding in antibody-based assays.
Compatibility with high-resolution imaging techniques for detailed analysis.
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