Recombinant Full Length Mouse Interleukin-1 Receptor-Like 1(Il1Rl1) Protein, His-Tagged

• Cat.No.: RFL10426MF
• Product Overview: Recombinant Full Length Mouse Interleukin-1 receptor-like 1(Il1rl1) Protein (P14719) (27-567aa), fused to N-terminal His tag, was expressed in E. coli.

Specification

• Source: E.coli expression system
• Species: Mus musculus (Mouse)
• Tag: His
• Form: Lyophilized powder
• Protein length: Full Length of Mature Protein (27-567)
• AA Sequence: SKSSWGLENEALIVRCPQRGRSTYP VEWYYSDTNESIPTQKRNRIFVSRD RLKFLPARVEDSGIYACVIRSPNLN KTGYLNVTIHKKPPSCNIPDYLMYS TVRGSDKNFKITCPTIDLYNWTAPV QWFKNCKALQEPRFRAHRSYLFIDN VTHDDEGDYTCQFTHAENGTNYIVT ATRSFTVEEKGFSMFPVITNPPYNH TMEVEIGKPASIACSACFGKGSHFL ADVLWQINKTVVGNFGEARIQEEEG RNESSSNDMDCLTSVLRITGVTEKD LSLEYDCLALNLHGMIRHTIRLRRK QPIDHRSIYYIVAGCSLLLMFINVL VIVLKVFWIEVALFWRDIVTPYKTR NDGKLYDAYIIYPRVFRGSAAGTHS VEYFVHHTLPDVLENKCGYKLCIYG RDLLPGQDAATVVESSIQNSRRQVF VLAPHMMHSKEFAYEQEIALHSALI QNNSKVILIEMEPLGEASRLQVGDL QDSLQHLVKIQGTIKWREDHVADKQ SLSSKFWKHVRYQMPVPERASKTAS VAAPLSGKACLDLKHF
• Purity: Greater than 90% as determined by SDS-PAGE.
• Applications: SDS-PAGE
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Tris/PBS-based buffer, 6% Trehalose, pH 8.0
• Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
• Gene Name: Il1rl1
• Synonyms: Il1rl1; Ly84; St2; Ste2; Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Lymphocyte antigen 84; Protein ST2; Protein T1
• UniProt ID: P14719

Gene Information

• Gene Name: Il1rl1
• Synonyms: Il1rl1; Ly84; St2; Ste2; Interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Lymphocyte antigen 84; Protein ST2; Protein T1
• UniProt ID: P14719

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.