Recombinant Full Length Mouse Putative Gamma-Secretase Subunit Aph-1C(Aph1C) Protein, His-Tagged
Cat.No. : | RFL21735MF |
Product Overview : | Recombinant Full Length Mouse Putative gamma-secretase subunit APH-1C(Aph1c) Protein (Q9DCZ9) (1-258aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Mus musculus (Mouse) |
Tag : | His |
Form : | Lyophilized powder |
Protein Length : | Full Length (1-258) |
AA Sequence : | MTLPVFFGCAFIAFGPAFALYLFTI ATDPLRVIFLIAGAFFWLVSLLLSS MFWFLVRVIT NNRDESVQNYLLIFGALLSVCIQEL FRLAYYKLLKKASEGLKSINPEEDI APSMRLLAYV SGLGFGIMSGVFSFVNTLSNSLGPG TVGIHGDSPQFFLNSAFMTLVVIML HVFWGVVFFD GCEKNKWYTLLTVLLTHLVVSTQTF LSPYYEVNLVTAYIIMVLMGIWAFY VAGGSCRSLK FCLLCQDKDFLLYNQRSR |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Aph1c |
Synonyms : | Aph1c; Putative gamma-secretase subunit APH-1C |
UniProt ID : | Q9DCZ9 |
Gene Name : | Aph1c |
Synonyms : | Aph1c; Putative gamma-secretase subunit APH-1C |
UniProt ID : | Q9DCZ9 |
Products Types
◆ Recombinant Protein | ||
APH1C-619M | Recombinant Mouse APH1C Protein, His (Fc)-Avi-tagged | +Inquiry |
APH1C-1769M | Recombinant Mouse APH1C Protein | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (18)
Ask a questionAPH1C could be used as a biomarker for early diagnosis of Alzheimer's disease.
APH1C is involved in the regulation of Notch signaling pathway in neurodegenerative diseases, thus affecting physiological functions of the nervous system.
APH1C is involved in Notch signaling pathway and can be used as a target for screening compound drugs.
APH1C is a transmembrane protein.
APH1C plays an important role in the regulation of tumor growth and metastasis, and therefore has the potential to treat cancer.
The expression of APH1C is related to gender, age, race and other factors.
APH1C is mainly located in the endoplasmic reticulum and Golgi apparatus.
APH1C is involved in the regulation of apoptosis.
APH1C is mainly associated with neurodegenerative diseases, tumors and other diseases, such as Alzheimer's disease, cancer, etc.
The gene for the APH1C has been associated with susceptibility to Alzheimer's disease, and the susceptibility mutations need to be further studied.
APH1C is involved in Notch signaling pathway.
The biological activity of APH1C can be evaluated by cell culture experiment and mouse model experiment.
Post-translational modifications of APH1C s can be detected by mass spectrometry and other methods.
The expression level of APH1C could be detected by Western blot, immunohistochemistry and other methods.
APH1C plays a key role in cell growth and differentiation.
PH1C can be used to design brain agonists as targets for anticancer drugs.
APH1C s interact with a variety of proteins, such as nicastrin, pen-2, etc.
APH1C is widely used in anticancer drug research and neurological disease drug research.
Customer Reviews (4)
Write a reviewLow carbon emissions and friendly to the environment.
The short half-life and high clearance characteristics of APH1C give it greater advantages in tissue penetration and better access to the lesion site.
Stability of APH1C is very good, and its performance remains unchanged after repeated use, which brings great convenience to our experiment.
Specificity in Western blot is very good, the binding ability to the target protein is strong, and the cross-reactivity is low, indicating that it has high specificity and low cross-reactivity.
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