Recombinant Human ABCA7 Protein Pre-coupled Magnetic Beads

• Cat.No.: ABCA7-2400H-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Human
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 [ Homo sapiens ]
• Official Symbol: ABCA7
• Gene ID: 10347
• mRNA Refseq: NM_019112.3
• Protein Refseq: NP_061985.2
• MIM: 605414
• UniProt ID: B3KUJ3

Reviews

06/19/2021

Rich catalog of recombinant protein products, no need to look for protein products everywhere.

07/12/2020

Customizable, very convenient

Q&As

Are your recombinant protein products full-length proteins or protein domains?

Our products have full-length proteins and protein parts, you can check the details in the product overview.

What biological processes are ABCA7 involved in?

ABCA7 is involved in lipid transport, phagocytosis, visual learning, and positive regulation of cholesterol efflux.

Do you have biotinylated ABCA7 protein products?

We do. Our products can be customized according to different needs of customers, and the labels that can be added include biotin, fluorescein, alexa flour, APC, etc.

How does abca7 contribute to AD-related pathology?

ABCA7 loss of function significantly increases amyloid precursor protein proteolysis and amyloid-β production.

Which expression systems can be used to express the abca7 gene?

Expression systems such as HEK293 and CHO can be used.

Can a GFP tag be added to study protein function?

Some studies added green fluorescent protein to the C-terminus of ABCA7, which did not affect the lipid release reaction.

Is the ABCA7 variant a susceptibility locus for late-onset AD?

Cumulative genetic evidence collected through genome-wide studies (GWAS) has identified ABCA7 variants as late-onset AD susceptibility loci, including rs3764650, rs3752246, and rs115550680.

How ABCA7 limits amyloid-beta production?

ABCA7 limits amyloid-β production by regulating amyloid-β A4 precursor protein endocytosis and/or processing.

Does ABCA7 transport phosphatidylcholine?

it does. But when phosphatidylcholine and phosphatidylserine are present at the same time, ABCA7 will preferentially transport phosphatidylserine.