Recombinant Human ACAA1, His-tagged
Cat.No. : | ACAA1-26046TH |
Product Overview : | Recombinant full length Human ACAA1 with an N terminal His tag; 419 amino acids including tag, MWt 43.8kDa. |
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Description : | This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. |
Protein length : | 398 amino acids |
Conjugation : | HIS |
Molecular Weight : | 43.800kDa |
Source : | E. coli |
Form : | Liquid |
Purity : | >95% by SDS-PAGE |
Storage buffer : | Preservative: NoneConstituents: 10% Glycerol, 0.1M Sodium chloride, 20mM Tris HCl, 1mM DTT, pH 8.0 |
Storage : | Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. |
Sequences of amino acids : | MGSSHHHHHHSSGLVPRGSHMLSGA PQASAADVVVVHGRRTAICRAGRGG FKDTTPDELLSAVMTAVLKDVNLRP EQLGDICVGNVLQPGAGAIMARIAQ FLSDIPETVPLSTVNRQCSSGLQAV ASIAGGIRNGSYDIGMACGVESMSL ADRGNPGNITSRLMEKEKARDCLIP MGITSENVAERFGISREKQDTFALA SQQKAARAQSKGCFQAEIVPVTTTV HDDKGTKRSITVTQDEGIRPSTTME GLAKLKPAFKKDGSTTAGNSSQVSD GAAAILLARRSKAEELGLPILGVLR SYAVVGVPPDIMGIGPAYAIPVALQ KAGLTVSDVDIFEINEAFASQAAYC VEKLRLPPEKVNPLGGAVALGHPLG CTGARQVITLLNELKRRGKRAYGVV SMCIGTGMGAAAVFEYPGN |
Sequence Similarities : | Belongs to the thiolase family. |
Gene Name : | ACAA1 acetyl-CoA acyltransferase 1 [ Homo sapiens ] |
Official Symbol : | ACAA1 |
Synonyms : | ACAA1; acetyl-CoA acyltransferase 1; acetyl Coenzyme A acyltransferase 1; 3-ketoacyl-CoA thiolase, peroxisomal; peroxisomal 3 oxoacyl Coenzyme A thiolase; |
Gene ID : | 30 |
mRNA Refseq : | NM_001130410 |
Protein Refseq : | NP_001123882 |
MIM : | 604054 |
Uniprot ID : | P09110 |
Chromosome Location : | 3p23-p22 |
Pathway : | Beta-oxidation of very long chain fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, organism-specific biosystem; Biosynthesis of unsaturated fatty acids, conserved biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem; |
Function : | acetyl-CoA C-acyltransferase activity; protein binding; transferase activity, transferring acyl groups other than amino-acyl groups; |
Products Types
◆ Recombinant Protein | ||
ACAA1-408H | Recombinant Human ACAA1 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
ACAA1-251H | Recombinant Human ACAA1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACAA1-302H | Recombinant Human ACAA1 Protein (27-331 aa), His-SUMO-tagged | +Inquiry |
ACAA1-784H | Recombinant Human Acetyl-CoA Acyltransferase 1, His-tagged | +Inquiry |
ACAA1-424Z | Recombinant Zebrafish ACAA1 | +Inquiry |
◆ Lysates | ||
ACAA1-9119HCL | Recombinant Human ACAA1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionModulating its activity could potentially treat metabolic disorders or enhance ketone body production.
It is a dimeric protein with a helix-turn-helix motif.
It plays a crucial role in beta-oxidation of fatty acids and ketone body synthesis.
It catalyzes the transfer of an acyl group from acyl-CoA to CoA.
It interacts with other enzymes in the beta-oxidation pathway, including acyl-CoA dehydrogenases and enoyl-CoA hydratases.
Its expression is regulated by transcription factors, hormones, and metabolic signals.
It is involved in the metabolism of long-chain fatty acids, branched-chain amino acids, and isoprenoids.
Deficiency can lead to metabolic disorders, such as hypoketotic hypoglycemia, while overexpression may increase ketone body production.
It is expressed in various tissues, including liver, adipose tissue, and muscle.
Dysregulation of its activity may contribute to the development of metabolic diseases such as diabetes and obesity.
Customer Reviews (2)
Write a reviewProvides high signal-to-noise ratio and low background in detection of the target protein in various assays.
Highly effective in blocking the activity of the target protein in functional studies.
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