Recombinant Human ACOT2 protein, His-tagged
Cat.No. : | ACOT2-3247H |
Product Overview : | Recombinant Human ACOT2 protein(222-483 aa), fused to His tag, was expressed in E. coli. |
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Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | The purified protein was Lyophilized from sterile PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH7.4). 5 % trehalose and 5 % mannitol are added as protectant before lyophilization. The elution buffer contain 300mM imidazole. |
Protein length : | 222-483 aa |
AA Sequence : | IVDMFGTGGGLLEYRASLLAGKGFA VMALAYYNYEDLPKTMETLHLEYFE EAMNYLLSHPEVKGPGVGLLGISKG GELCLSMASFLKGITAAVVINGSVA NVGGTLRYKGETLPPVGVNRNRIKV TKDGYADIVDVLNSPLEGPDQKSFI PVERAESTFLFLVGQDDHNWKSEFY ANEACKRLQAHGRRKPQIICYPETG HYIEPPYFPLCRASLHALVGSPIIW GGEPRAHVMAQVDAWKQLQTFFHKH LGGHEGTIPSKV |
Purity : | 95%, by SDS-PAGE with Coomassie Brilliant Blue staining. |
Storage : | Short-term storage: Store at 2-8°C for (1-2 weeks). Long-term storage: Aliquot and store at -20°C to -80°C for up to 3 months, buffer containing 50% glycerol is recommended for reconstitution. Avoid repeat freeze-thaw cycles. |
Reconstitution : | Reconstitute at 0.25 µg/μl in 200 μl sterile water for short-term storage. Reconstitution with 200 μl 50% glycerol solution is recommended for longer term storage. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (13)
Ask a questionACOT2 protein may have therapeutic implications for the treatment of metabolic disorders such as obesity and diabetes, as well as certain types of cancer. It may also be a target for drug development to enhance fatty acid oxidation.
ACOT2 protein may be used as a diagnostic biomarker for metabolic disorders or cancer, but more research is needed to establish its clinical utility.
One of the challenges is the lack of specificity of current inhibitors and modulators of ACOT2 activity. Additionally, more research is needed to fully understand the role of ACOT2 in various diseases and to validate its potential as a therapeutic target.
ACOT2 protein is not commonly used in diagnostic tests, but changes in its expression or activity may serve as biomarkers for certain diseases or conditions.
Common techniques used to study ACOT2 protein and its function include molecular biology and biochemistry techniques such as gene expression analysis, enzyme assays, and protein purification. Imaging techniques such as fluorescent microscopy may also be used to visualize ACOT2 localization and function within cells.
ACOT2 protein expression levels may have the potential to identify individuals who would benefit from specific treatments for metabolic disorders or cancer, allowing for personalized treatment plans.
There are currently no FDA-approved drugs that target ACOT2 protein activity, but researchers are investigating potential inhibitors and modulators of ACOT2 as therapeutic agents for metabolic disorders and cancer.
ACOT2 protein has potential applications in drug development for metabolic disorders and obesity. It also has applications in research as a biomarker for poor prognosis in cancer patients and as a therapeutic target for cancer treatment.
There have been some studies that suggest variations in the ACOT2 gene may be associated with increased risk for obesity and metabolic disorders. However, more research is needed to establish these links definitively.
Research areas exploring the potential of ACOT2 protein include metabolic disorders such as diabetes and obesity, as well as cancer research and drug development.
There is ongoing research to further understand ACOT2's role in lipid metabolism and its potential therapeutic targets in diseases such as obesity and cancer. Additionally, there is interest in developing more specific and effective inhibitors or modulators of ACOT2 activity for potential therapeutic use.
One challenge is understanding the complex role of ACOT2 in lipid metabolism and its potential off-target effects on other metabolic pathways. Developing selective ACOT2 inhibitors or modulators with good pharmacokinetic properties is also a challenge.
ACOT2 protein expression and activity are regulated by a variety of factors, including hormones, nutrient availability, and cellular energy status. Other enzymes and proteins involved in lipid metabolism may also impact ACOT2 activity.
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