Acot2
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Official Full Name
acyl-CoA thioesterase 2
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Synonyms
ACOT2; MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128; acyl-coenzyme A thioesterase 2, mitochondrial; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; acyl-coenzyme A thioester hydrolase 2a; peroxisomal long-chain acyl-coA thioesterase 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ACOT2-3139H | Recombinant Human ACOT2, His-tagged | E.Coli or Yeast | His | 483 | |
Human | ACOT2-12H | Recombinant Human ACOT2 protein, GST-tagged | Wheat Germ | GST | ||
Human | ACOT2-3247H | Recombinant Human ACOT2 protein, His-tagged | E.coli | His | 222-483 aa | |
Human | ACOT2-583HF | Recombinant Full Length Human ACOT2 Protein, GST-tagged | In Vitro Cell Free System | GST | 483 amino acids | |
Rat | Acot2-3138R | Recombinant Rat Acot2, His-tagged | E.Coli or Yeast | His | 453 | |
Cynomolgus Monkey | ACOT2-267C | Recombinant Cynomolgus ACOT2 Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | ACOT2-266C | Recombinant Cynomolgus ACOT2 Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | ACOT2-16C | Recombinant Cynomolgus Monkey ACOT2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | ACOT2-16C-B | Recombinant Cynomolgus Monkey ACOT2 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- Acot2 Related Articles
Acot2 involved in several pathways and played different roles in them. We selected most pathways Acot2 participated on our site, such as Biosynthesis of unsaturated fatty acids, Fatty Acyl-CoA Biosynthesis, Fatty acid elongation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Acot2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Biosynthesis of unsaturated fatty acids | ACOX3;BAAT;TECR;PTPLAD2;HSD17B12B;HADHA;ACOT7;SCDB;Scd1 |
Fatty Acyl-CoA Biosynthesis | ACOT11;ACOT11A;THEM5;ACOT11B;SLC25A1;ACOT9.2;ACOT9;ACOT2;ELOVL1A |
Fatty acid elongation | ELOVL1;HADHB;HADH;ACOT1;ELOVL3;ELOVL6;PTPLA;ELOVL4;ACOT2 |
Fatty acid, triacylglycerol, and ketone body metabolism | AGPAT6;MED22;ACOT9.2;SLC25A20;ACOT9;GLIPR1;ACOT13;ACOT11;MED8 |
Metabolic pathways | NT5M;GPT2L;MAPK1IP1L;HOGA1;RDH10;B3GNT2;PDHX;CYP19A1;AMPD1 |
Metabolism | FAM96B;CLPS;CYP3A7-CYP3AP1;SLC25A32A;SLC27A5;ABHD4;COX4I1;ADSS;OAZ1A |
Metabolism of lipids and lipoproteins | SLC27A2;ACOT2;STARD5;FAAH2;HSD17B11;ACSF2;CEPT1A;ACSF3;ACOT9.1 |
Ovarian steroidogenesis | HSD3B5;PTGS2;HSD3B1;PLA2G4F;INSR;GNAS;INS2;HSD17B7;PLA2G4A |
Acot2 has several biochemical functions, for example, acyl-CoA hydrolase activity, carboxylic ester hydrolase activity, palmitoyl-CoA hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Acot2 itself. We selected most functions Acot2 had, and list some proteins which have the same functions with Acot2. You can find most of the proteins on our site.
Function | Related Protein |
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acyl-CoA hydrolase activity | ACSBG2;ACOT1;ACOT10;ACOT2;ACOT8;ACOT5;ACOT11 |
carboxylic ester hydrolase activity | Cel;LIPCA;ACOT9;Aadacl3;ACOT1;ACOT6;ACOT5;ACOT8;LIPH |
palmitoyl-CoA hydrolase activity | ACOT8;GNPAT;ACOT5;BAAT;ACOT1;PPT1;ACOT7;ACOT2;THEM4 |
receptor binding | WNT2BB;SLC39A1;PTPRD;FGF6A;MYO1C;TYROBP;CROT;AKAP9;BMP2 |
Acot2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Acot2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Acot2.
ZNF277
- Q&As
- Reviews
Q&As (13)
Ask a questionACOT2 protein may have therapeutic implications for the treatment of metabolic disorders such as obesity and diabetes, as well as certain types of cancer. It may also be a target for drug development to enhance fatty acid oxidation.
ACOT2 protein may be used as a diagnostic biomarker for metabolic disorders or cancer, but more research is needed to establish its clinical utility.
One of the challenges is the lack of specificity of current inhibitors and modulators of ACOT2 activity. Additionally, more research is needed to fully understand the role of ACOT2 in various diseases and to validate its potential as a therapeutic target.
ACOT2 protein is not commonly used in diagnostic tests, but changes in its expression or activity may serve as biomarkers for certain diseases or conditions.
Common techniques used to study ACOT2 protein and its function include molecular biology and biochemistry techniques such as gene expression analysis, enzyme assays, and protein purification. Imaging techniques such as fluorescent microscopy may also be used to visualize ACOT2 localization and function within cells.
ACOT2 protein expression levels may have the potential to identify individuals who would benefit from specific treatments for metabolic disorders or cancer, allowing for personalized treatment plans.
There are currently no FDA-approved drugs that target ACOT2 protein activity, but researchers are investigating potential inhibitors and modulators of ACOT2 as therapeutic agents for metabolic disorders and cancer.
ACOT2 protein has potential applications in drug development for metabolic disorders and obesity. It also has applications in research as a biomarker for poor prognosis in cancer patients and as a therapeutic target for cancer treatment.
There have been some studies that suggest variations in the ACOT2 gene may be associated with increased risk for obesity and metabolic disorders. However, more research is needed to establish these links definitively.
Research areas exploring the potential of ACOT2 protein include metabolic disorders such as diabetes and obesity, as well as cancer research and drug development.
There is ongoing research to further understand ACOT2's role in lipid metabolism and its potential therapeutic targets in diseases such as obesity and cancer. Additionally, there is interest in developing more specific and effective inhibitors or modulators of ACOT2 activity for potential therapeutic use.
One challenge is understanding the complex role of ACOT2 in lipid metabolism and its potential off-target effects on other metabolic pathways. Developing selective ACOT2 inhibitors or modulators with good pharmacokinetic properties is also a challenge.
ACOT2 protein expression and activity are regulated by a variety of factors, including hormones, nutrient availability, and cellular energy status. Other enzymes and proteins involved in lipid metabolism may also impact ACOT2 activity.
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