Recombinant Human ACOT4 Protein Pre-coupled Magnetic Beads

• Cat.No.: ACOT4-260H-B
• Product Overview: The Recombnant protein was conjugated to magnetic beads. This ready-to-use, pre-coupled magnetic beads are in uniform particle size and narrow size distribution with large surface area, which is conducive to convenient and fast capture target molecules with high specificity and achieve magnetic separation. This product can be equipped with automation equipment for high-throughput operations.

Specification

• Source: HEK293
• Species: Human
• Form: Solution
• Particle size: ~2 μm
• Beads Surface: Hydrophilic
• Capacity: > 200 pmol rabbit IgG/ mg beads
• Applications: Immunoassay, In vitro diagnostics, cell sorting, Immunoprecipitation/Co-precipitation, Protein/antibody separation and purification.
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions.
• Storage: 2-8℃. Do not to freeze thaw the Beads
• Concentration: 10mg beads/mL
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: ACOT4 acyl-CoA thioesterase 4 [ Homo sapiens (human) ]
• Official Symbol: ACOT4
• Synonyms: PTE1B; PTE2B; PTE-Ib
• Gene ID: 122970
• mRNA Refseq: NM_152331.4
• Protein Refseq: NP_689544.3
• MIM: 614314
• UniProt ID: Q8N9L9

Q&As

What are some ethical considerations surrounding the development of ACOT4 inhibitors?

As with any new drug development, there are ethical considerations to be taken into account, including issues related to patient safety, access to treatment, and pricing. Additionally, the use of animal models in preclinical testing raises ethical concerns, and efforts should be made to minimize animal suffering and ensure the humane treatment of animals used in research.

How might ACOT4 protein be used in drug discovery?

Researchers may use ACOT4 protein as a target to screen for potential drugs that inhibit or modulate its activity. Additionally, the protein could be used to test the efficacy of drugs already in development for cancer treatment.

What are some potential applications of ACOT4 protein in medicine?

ACOT4 has been implicated in various cancers, including prostate and breast cancer, so potential applications could include developing drugs that target ACOT4 to treat or prevent these types of cancer.

What other potential applications of ACOT4 inhibitors are being explored?

ACOT4 inhibitors are also being studied for their potential to treat metabolic disorders, such as obesity and type 2 diabetes, due to their ability to regulate lipid metabolism. Additionally, ACOT4 has been implicated in neurological disorders, such as Alzheimer's disease, so ACOT4 inhibitors could have potential in these areas as well.

What are the potential cancer treatment applications of ACOT4 protein?

ACOT4 has been identified as a potential target for cancer treatment because it plays a critical role in lipid metabolism, which is essential for cancer cell growth and survival. Inhibiting ACOT4 has been shown to reduce cancer cell growth, induce apoptosis (programmed cell death), and sensitize tumor cells to chemotherapy.

Are there any other potential applications of ACOT4 protein aside from cancer treatment?

Yes, there are potential applications of ACOT4 in other areas of research. For example, some studies have suggested that ACOT4 may play a role in the regulation of lipid metabolism, which could have implications for cardiovascular disease and other metabolic disorders. Additionally, ACOT4 has been shown to play a role in brain function, so it could potentially be targeted to treat neurological disorders.

How could ACOT4 inhibitors be developed for cancer treatment?

ACOT4 inhibitors could be developed as small molecule drugs or antibody therapies that target the protein specifically. Researchers have already identified several compounds that can inhibit ACOT4 activity, and further development and testing is needed to determine their effectiveness as cancer therapies.

Could ACOT4 protein be used in diagnostic tests for cancer?

There is currently no evidence that ACOT4 protein could be used in diagnostic tests for cancer. However, further research on its role in cancer metabolism and growth could potentially lead to the development of diagnostic tests in the future.

Are there any potential side effects or risks associated with targeting ACOT4 for therapeutic purposes?

Because there are currently no drugs available that specifically target ACOT4, it is difficult to say what potential side effects or risks could arise from such therapies. However, as with any drug, there could be potential side effects and risks that would need to be carefully considered and evaluated in clinical trials.

How is ACOT4 protein different from other proteins involved in cancer metabolism?

ACOT4 is an acyl-CoA thioesterase, which means it catalyzes the hydrolysis of acyl-CoA esters to release free fatty acids. Other enzymes involved in cancer metabolism include lactate dehydrogenase, which converts pyruvate to lactate in order to generate energy, and hexokinase, which catalyzes the first step in glycolysis. While these enzymes all play different roles in cancer metabolism, they are all potential targets for cancer therapies.

Could ACOT4 protein be used as a biomarker for cancer?

There is increasing evidence to suggest that ACOT4 could be used as a prognostic biomarker for certain types of cancer, such as prostate and breast cancer. It could potentially be used to determine the stage and severity of the cancer, as well as to monitor treatment.

Are there any current drugs that target ACOT4?

There are currently no drugs available that specifically target ACOT4. However, there are drugs that target other enzymes involved in cancer metabolism, such as inhibitors of lactate dehydrogenase.

How is ACOT4 protein studied in the laboratory?

Researchers use various techniques to study ACOT4 protein, including western blotting, immunofluorescence, and enzyme assays. They may also use CRISPR-Cas9 gene editing technology to knock out ACOT4 in cell lines and study the effects on cancer growth and metabolism. Animal models are also used to study the role of ACOT4 in cancer and other diseases.

Are there any challenges to developing ACOT4 inhibitors for cancer treatment?

One challenge is that ACOT4 is also expressed in normal cells, so any drug that targets it would need to be selective for cancer cells to avoid damaging healthy tissue. Additionally, cancer cells may develop resistance to ACOT4 inhibitors over time, so combination therapies with other drugs may be needed to overcome resistance.