Recombinant Human ACTG2 293 Cell Lysate
Cat.No. : | ACTG2-9063HCL |
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Description : | Antigen standard for actin, gamma 2, smooth muscle, enteric (ACTG2) is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. Protein concentration was determined using a colorimetric assay. The antigen control carries a C-terminal Myc/DDK tag for detection. |
Source : | HEK 293 cells |
Species : | Human |
Components : | This product includes 3 vials: 1 vial of gene-specific cell lysate, 1 vial of control vector cell lysate, and 1 vial of loading buffer. Each lysate vial contains 0.1 mg lysate in 0.1 ml (1 mg/ml) of RIPA Buffer (50 mM Tris-HCl pH7.5, 250 mM NaCl, 5 mM EDTA, 50 mM NaF, 1% NP40). The loading buffer vial contains 0.5 ml 2X SDS Loading Buffer (125 mM Tris-Cl, pH6.8, 10% glycerol, 4% SDS, 0.002% Bromophenol blue, 5% beta-mercaptoethanol). |
Size : | 0.1 mg |
Storage Instruction : | Store at -80°C. Minimize freeze-thaw cycles. After addition of 2X SDS Loading Buffer, the lysates can be stored at -20°C. Product is guaranteed 6 months from the date of shipment. |
Applications : | ELISA, WB, IP. WB: Mix equal volume of lysates with 2X SDS Loading Buffer. Boil the mixture for 10 min before loading (for membrane protein lysates, incubate the mixture at room temperature for 30 min). Load 5 ug lysate per lane. |
Gene Name : | ACTG2 actin, gamma 2, smooth muscle, enteric [ Homo sapiens ] |
Official Symbol : | ACTG2 |
Synonyms : | ACTG2; actin, gamma 2, smooth muscle, enteric; ACTA3, ACTL3; actin, gamma-enteric smooth muscle; ACTSG; alpha-actin 3; alpha-actin-3; gamma-2-actin; actin-like protein; smooth muscle gamma actin; smooth muscle gamma-actin; ACT; ACTE; ACTA3; ACTL3; |
Gene ID : | 72 |
mRNA Refseq : | NM_001199893 |
Protein Refseq : | NP_001186822 |
MIM : | 102545 |
UniProt ID : | P63267 |
Chromosome Location : | 2p13.1 |
Pathway : | Muscle contraction, organism-specific biosystem; Smooth Muscle Contraction, organism-specific biosystem; Vascular smooth muscle contraction, organism-specific biosystem; Vascular smooth muscle contraction, conserved biosystem; |
Function : | ATP binding; nucleotide binding; |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (18)
Ask a questionACTG2 has been found to have a critical role in HCC tumor metastasis.
Yes, ACTG2 expression can be regulated by various signaling pathways and transcription factors specific to smooth muscle cells.
ACTG2 inhibits cell growth in vitro.
While ACTG2 is primarily expressed in smooth muscle tissues, low levels of expression have also been detected in other tissues, suggesting potential additional functions.
The ACTG2 gene encodes the protein actin gamma-2, which is involved in muscle contraction and smooth muscle function.
Yes, mutations in the ACTG2 gene have been linked to a group of rare disorders called visceral myopathy, which affect the function of smooth muscles in the gastrointestinal tract.
ACTG2 can interact with various proteins involved in cytoskeletal organization and muscle contraction, such as myosin and other actin-binding proteins
ACTG2 is an essential component of the actin cytoskeleton in smooth muscle cells, providing structural support and facilitating the contraction of these muscles.
Yes, ACTG2 is regarded as a novel target for the treatment of HCC.
The discovery of ACTG2's role provides valuable insights for further understanding and potentially treating HCC.
ACTG2 is expressed in a fraction of small intestine neuroendocrine tumors (SI-NETs).
miR-145 positively regulates the expression of ACTG2.
Given its role in smooth muscle function, ACTG2 may hold therapeutic potential for conditions involving smooth muscle dysfunction, such as gastrointestinal motility disorders.
ACTG2 is primarily expressed in smooth muscle tissues, including the smooth muscle cells of the gastrointestinal tract, blood vessels, and uterus.
Symptoms of ACTG2-related visceral myopathy can include gastrointestinal dysmotility, constipation, difficulty swallowing, and other digestive issues.
The ACTG2 protein belongs to the actin family and has a globular structure composed of multiple subunits that form filaments.
Yes, targeting ACTG2 holds promise as a potential therapeutic approach for treating HCC.
The findings suggest potential therapeutic strategies for small intestine neuroendocrine tumors (SI-NETs) based on ACTG2 and its regulation by miR-145.
Customer Reviews (5)
Write a reviewOur experiments consistently demonstrate that the protein product effectively promotes cell proliferation and growth.
The purity of the protein is evident from the absence of any contaminants, ensuring reliable and accurate results.
We have used the protein product across multiple experiments, and its performance has remained consistent throughout.
The shipping process was expedited, ensuring timely delivery of the product to our laboratory.
The company's customer support team has been extremely helpful, promptly addressing any technical or scientific inquiries.
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