Recombinant Human Activin A Receptor Type II-Like 1
Cat.No. : | ACVRL1-483H |
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Cat. No. : | ACVRL1-483H |
Description : | Activin A receptor type II-like 1, also known as ACVRL1, is a human gene. ACVRL1 is a receptor in the TGF beta signaling pathway. It is also known as "activin receptor-like kinase 1", or "ALK1". This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 suggesting a critical role for ALK-1 in the control of blood vessel development or repair. |
Source : | Mammalian cells |
Molecular Weight : | The predicted molecular weight of Recombinant Human ALK-1 is Mr 37.3 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 50-55 kDa. |
State Of Matter : | Lyophilized. |
Purity : | > 90% by SDS Page and analyzed by silver stain. |
Endotoxin : | < 1.0 EU/µg as determined by the LAL method. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. |
Gene Name : | ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ] |
Synonyms : | ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; serine/threonine-protein kinase receptor R3; EC 2.7.11.30 |
Gene ID : | 94 |
mRNA Refseq : | NM_000020 |
Protein Refseq : | NP_000011 |
UniProt ID : | P37023 |
Chromosome Location : | 12q11-q14 |
MIM : | 601284 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function : | ATP binding; SMAD binding; activin receptor activity, type I; magnesium ion binding; nucleotide binding; receptor activity; transferase activity; transforming growth factor beta binding |
Products Types
◆ Recombinant Protein | ||
Acvrl1-2333M | Active Recombinant Mouse Acvrl1 protein(Met1-Pro119), His&hFc-tagged | +Inquiry |
ACVRL1-276H | Recombinant Human ACVRL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVRL1-1186C | Active Recombinant Cynomolgus ACVRL1 protein(Met1-Gln118), His-tagged | +Inquiry |
ACVRL1-090H | Recombinant Human ACVRL1 Protein, His-tagged | +Inquiry |
ACVRL1-1154H | Recombinant Human ACVRL1 Protein, MYC/DDK-tagged | +Inquiry |
◆ Lysates | ||
ACVRL1-2629HCL | Recombinant Human ACVRL1 cell lysate | +Inquiry |
ACVRL1-3001RCL | Recombinant Rat ACVRL1 cell lysate | +Inquiry |
ACVRL1-994CCL | Recombinant Canine ACVRL1 cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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