Recombinant Human Activin A Receptor Type II-like 1, GST-tagged, Active
Cat.No. : | ACVRL1-238H |
Product Overview : | Recombinant human ALK1 (144-end) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW=64 kDa. |
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Cat. No. : | ACVRL1-238H |
Description : | ALK1 is a serine/threonine-protein kinase receptor R3 precursor that mediates signal by TGFβ superfamily. ALK1 functions as a TGFβ type I receptor in endothelial cells and is responsible for human hereditary hemorrhagic telangiectasia (HHT) type II. Distinct Smad proteins (i.e., Smad2/Smad3 and Smad1/Smad5) show interaction with ALK1 and mediate TGFβ signaling. Northern blot and RT-PCR analysis show that ALK1 specifically induces expression of Smad6, Smad7, Id1, Id2, endoglin, STAT1, and interleukin 1 receptor in endothelial cells. ALK1 expression in inflammatory myofibroblastic tumor of the urinary bladder have also has been reported. |
Source : | Sf9 insect cells using baculovirus. |
Sequence : | 144-end. |
Applications : | Kinase Assay, Western Blot. |
Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name : | ACVRL1 activin A receptor type II-like 1 [ Homo sapiens ] |
Synonyms : | ACVRL1; activin A receptor type II-like 1; HHT; ALK1; HHT2; ORW2; SKR3; ALK-1; TSR-I; ACVRLK1; activin A receptor type II-like 1; TGF-B superfamily receptor type I; activin A receptor, type II-like kinase 1; serine/threonine-protein kinase receptor R3; EC 2.7.11.30 |
Gene ID : | 94 |
mRNA Refseq : | NM_000020 |
Protein Refseq : | NP_000011 |
MIM : | 601284 |
UniProt ID : | P37023 |
Chromosome Location : | 12q11-q14 |
Pathway : | Cytokine-cytokine receptor interaction; TGF-beta signaling pathway |
Function : | ATP binding; SMAD binding; activin receptor activity, type I; magnesium ion binding; nucleotide binding; receptor activity; transferase activity; transforming growth factor beta binding |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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