Recombinant Human ACVR2B protein(Met1-Thr134), hFc-tagged
Cat.No. : | ACVR2B-196H |
Product Overview : | Recombinant Human ACVR2B (NP_001097.2)(Met 1-Thr 134) was expressed in HEK293 with the fused Human IgG1 Fc region at the C-terminus. |
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Source : | HEK293 |
Species : | Human |
Tag : | C-hFc |
Protein length : | Met1-Thr134 |
Form : | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Bio-activity : | 1. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.02-0.1 μg/mL in the presence of 10 ng/mL recombinant Activin A. 2. Measured by its binding ability in a functional ELISA. Immobilized Inhibin Human, Mouse, Rat, Cynomolgus, Rhesus Inhibin beta A/Activin A at 2 μg/ml (100 μl/well) can bind Human ACVR2B hFc, the EC50 of Human ACVR2B hFc is 12-60 ng/mL. |
Molecular Mass : | The recombinant human ACVR2B/Fc chimera is a disulfide-linked homodimer generated after removal of the signal peptide. The reduced monomer comprises 354 amino acids and predicts a molecular mass of 40.0 kDa. As a result of glycosylation, the monomer migrates as an approximately 60-65 kDa protein in SDS-PAGE under reducing conditions. |
Endotoxin : | < 1.0 EU per μg of the protein as determined by the LAL method |
Purity : | > 97 % as determined by SDS-PAGE |
Storage : | Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents. |
Publication : |
Combined detection of the ActRII‐Fc fusion proteins Sotatercept (ActRIIA‐Fc) and Luspatercept (modified ActRIIB‐Fc) in serum by means of immunoaffinity purification, tryptic digestion, and LC‐MS/MS (2018)
Development of two complementary LC–HRMS methods for analyzing sotatercept in dried blood spots for doping controls (2019)
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Gene Name : | ACVR2B activin A receptor, type IIB [ Homo sapiens ] |
Official Symbol : | ACVR2B |
Synonyms : | ACVR2B; activin A receptor, type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB; |
Gene ID : | 93 |
mRNA Refseq : | NM_001106 |
Protein Refseq : | NP_001097 |
MIM : | 602730 |
UniProt ID : | Q13705 |
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ACVR2B-1155H | Recombinant Human ACVR2B Protein, MYC/DDK-tagged | +Inquiry |
ACVR2B-197H | Recombinant Human ACVR2B protein(Met1-Thr134), His-tagged | +Inquiry |
ACVR2B-084H | Recombinant Human ACVR2B Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ACVR2B-734CCL | Recombinant Cynomolgus ACVR2B cell lysate | +Inquiry |
ACVR2B-2540MCL | Recombinant Mouse ACVR2B cell lysate | +Inquiry |
ACVR2B-2724HCL | Recombinant Human ACVR2B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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