Recombinant Human ADAM2

• Cat.No.: ADAM2-26413TH
• Product Overview: Recombinant full length Human ADAM2, isoform 2 with N terminal proprietary tag. Predicted MW 104.76 kDa.

Specification

• Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.
• Protein length: 716 amino acids
• Molecular Weight: 104.760kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Expressed specifically in spermatogenic cells in the seminiferous cells. Not detected in fetal tissues.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.3% Glutathione, 0.79% Tris HCl
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: MWRVLFLLSGLGGLRMDSNFDSLPVQITVPEKIRSIIKEG IESQASYKIVIEGKPYTVNLMQKNFLPHNFRVYSYSGTGI MKPLDQDFQNFCHYQGYIEGYPKSVVMVSTCTGLRGVLQF ENVSYGIEPLESSVGFEHVIYQVKHKKADVSLYNEKDIES RDLSFKLQSVEYNHMGSDTTVVAQKVFQLIGLTNAIFVSF NITIILSSLELWIDENKIATTGEANELLHTFLRWKTSYLV LRPHDVAFLLVYREKSNYVGATFQGKMCDANYAGGVVLHP RTISLESLAVILAQLLSLSMGITYDDINKCQCSGAVCIMN PEAIHFSGVKIFSNCSFEDFAHFISKQKSQCLHNQPRLDP FFKQQAVCGNAKLEAGEECDCGTEQDCALIGETCCDIATC RFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCN GSSASCPENHYVQTGHPCGLNQWICIDGVCMSGDKQCTDT FGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADN LQCGKLICKYVGKFLLQIPRATIIYANISGHLCIAVEFAS DHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTD KCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSG NFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIF CVLIAIMVKVNFQRKKWRTEDYSSDEQPESESEPKG
• Sequence Similarities: Contains 1 disintegrin domain.Contains 1 EGF-like domain.Contains 1 peptidase M12B domain.

Gene Information

• Gene Name: ADAM2 ADAM metallopeptidase domain 2 [ Homo sapiens ]
• Official Symbol: ADAM2
• Synonyms: ADAM2; ADAM metallopeptidase domain 2; fertilin beta , FTNB; disintegrin and metalloproteinase domain-containing protein 2; cancer/testis antigen 15; CT15; PH 30b; PH30
• Gene ID: 2515
• mRNA Refseq: NM_001464
• Protein Refseq: NP_001455
• MIM: 601533
• Uniprot ID: Q99965
• Chromosome Location: 8p11.2
• Function: integrin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding

Reviews

06/18/2021

The technician was very professional and helped me solve many problems that arose in my experiments.

01/26/2021

Customer service is always online and able to answer my questions in a timely manner.

07/11/2020

High protein concentration and good quality for my experimental needs.

Q&As

What is ADAM2 also known as?

ADAM2 also known as PH-30 β or fertilin β.

Where is the cellular localization of ADAM2?

ADAM2 is localized in the cell membrane.

Where is ADAM2 synthesized?

ADAM2 is synthesized in the testes and processed during sperm maturation.

What is the biological function of ADAM2?

ADAM2 contribute to sperm-sperm adhesion, sperm-egg interactions, and the migration of sperm in the female reproductive tract.

What are the effects of ADAM2 deficiency?

ADAM2 deficiency causes sterility in male mice.