Recombinant Human ADAM21 Protein, GST-tagged

• Cat.No.: ADAM21-282H
• Product Overview: Human ADAM21 full-length ORF ( NP_003804.1, 1 a.a. - 722 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 107.2 kDa
• AA Sequence: MAVDGTLVYIRVTLLLLWLGVFLSI SGYCQAGPSQHFTSPEVVIPLKVIS RGRSAKAPGWLSYSLRFGGQKHVVH MRVKKLLVSRHLPVFTYTDERALLE DQLFIPDDCYYHGYVEGAPESLVVF SACFGGFRGVLKISGLTYEIEPIRH SATFEHLVYKVNSNETQFPAMRCGL TEKEVARQQLEFEEAENSALEPKSA GDWWTHAWFLELVVVVNHDFFIYSQ SNISKVQEDVFLVVNIVDSMYQQLG TYIILIGIEIWNQGNVFPMTSIEQV LNDFSQWKQISLSQLQHDAAHMFIK NSLISILGLAYVAGICRPPIDCGVD NFQGDTWSLFANTVAHELGHTLGMQ HDEEFCFCGERGCIMNTFRVPAEKF TNCSYADFMKTTLNQGSCLHNPPRL GEIFMLKRCGNGVVEREEQCDCGSV QQCEQDACCLLNCTLRPGAACAFGL CCKDCKFMPSGELCRQEVNECDLPE WCNGTSHQCPEDRYVQDGIPCSDSA YCYQKRCNNHDQHCREIFGKDAKSA SQNCYKEINSQGNRFGHCGINGTTY LKCHISDVFCGRVQCENVRDIPLLQ DHFTLQHTHINGVTCWGIDYHLRMN ISDIGEVKDGTVCGPGKICIHKKCV SLSVLSHVCLPETCNMKGICNNKHH CHCGYGWSPPYCQHRGYGGSIDSGP ASAKRGVFLPLIVIPSLSVLTFLFT VGLLMYLRQCSGPKETKAHSSG
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: ADAM21 ADAM metallopeptidase domain 21 [ Homo sapiens ]
• Official Symbol: ADAM21
• Synonyms: ADAM21; ADAM metallopeptidase domain 21; a disintegrin and metalloproteinase domain 21; disintegrin and metalloproteinase domain-containing protein 21; ADAM31; ADAM metallopeptidase domain 21, preproprotein; ADAM 21; MGC125389
• Gene ID: 8747
• mRNA Refseq: NM_003813
• Protein Refseq: NP_003804
• MIM: 603713
• UniProt ID: Q9UKJ8

Reviews

10/22/2022

The products provided by your company are of good value and quality, and it is a satisfactory shopping experience!

06/22/2021

The ADAM21 protein purchased was suitable for WB experiments and the experiments went very well and satisfactory results were obtained.

12/10/2020

The technician suggested modifications to my experimental protocol to make my experiment go smoothly.

Q&As

Where is ADAM21 abundantly expressed?

ADAM21 is abundantly expressed in testicular somatic cells.

Does ADAM21 knockout affect fertility in mice?

The current study demonstrates that male mice deficient in Adam21 are normally fertile.

How ADAM21 knockdown affects hepatocellular carcinoma cells?

ADAM21 knockdown inhibits HCC cell proliferation, migration, and invasion and induces cell-cycle arrest and apoptosis.

Which proteins have the highest homology to ADAM21?

ADAM20 and ADAM9 have the highest homology to ADAM21.

In which diseases is ADAM21 used in research?

ADAM21 applied in the study of hepatocellular carcinoma.