Recombinant Human ADAMTS13

• Cat.No.: ADAMTS13-26136TH
• Product Overview: Recombinant fragment corresponding to amino acids 1328-1427 of Human ADAMTS13 with a propreitary tag at N-terminal; predicted mwt: 36.63 kDa.

Specification

• Description: This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
• Molecular Weight: 36.630kDa inclusive of tags
• Source: Wheat germ
• Tissue specificity: Plasma. Expressed primarily in liver.
• Form: Liquid
• Purity: Proprietary Purification
• Storage buffer: pH: 8.00Constituents:0.79% Tris HCl, 0.31% Glutathione
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequences of amino acids: FINVAPHARIAIHALATNMGAGTEG ANASYILIRDTHSLRTTAFHGQQVL YWESESSQAEMEFSEGFLKAQASLR GQYWTLQSWVPEMQDPQSWKGKEGT
• Sequence Similarities: Contains 2 CUB domains.Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 8 TSP type-1 domains.

Gene Information

• Gene Name: ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 [ Homo sapiens ]
• Official Symbol: ADAMTS13
• Synonyms: ADAMTS13; ADAM metallopeptidase with thrombospondin type 1 motif, 13; a disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13 , C9orf8; A disintegrin and metalloproteinase with thrombospondin motifs 13; DKFZp434C2322
• Gene ID: 11093
• mRNA Refseq: NM_139025
• Protein Refseq: NP_620594
• MIM: 604134
• Uniprot ID: Q76LX8
• Chromosome Location: 9q34
• Function: calcium ion binding; integrin binding; metalloendopeptidase activity; metallopeptidase activity; metallopeptidase activity

Reviews

07/21/2021

The ADAM6TS13 proteins purchased from your company is suitable for ELISA.

07/10/2021

Customer service was patient and careful, solved all kinds of problems for me.

06/12/2021

The technician answered my questions in detail and helped me to get the desired results.

Q&As

Will all ADAMTS13 participate in this event?

Yes, all ADAMTS13 are eligible for this promotion, including proteins that require custom production.

Are there other expression systems available for ADAMTS13?

We have multiple expression systems, including bacterial expression systems, baculovirus-insect cell expression systems, cell-free in vitro protein expression systems, mammalian expression systems, yeast expression systems, etc.

Where is ADAMTS13 mainly synthesized?

ADAMTS13 is mainly synthesized in the liver.

What are the components of ADAMTS13?

ADAMTS13 consists of signal peptide, leader peptide, metalloproteinase domain, disintegrin-like domain, thrombospondin domain 1, a cysteine-rich domain, a spacer, a TSP motif region and two CUB domains.

Where is ADAMTS13 mainly located?

Using mCherry fluorescent protein labeling of ADAMTS13, it was found that it was mainly localized to the top of the thrombus.

What is the biological function of ADAMTS13?

ADAMTS13 can inhibit the inflammatory response by cleaving vascular hemophilic factors to reduce inflammatory response and thus reduce vascular endothelial function deficits.

What is ADAMTS13 also called?

ADAMTS13 cleaves the active supervascular hemophilia factor (vWF) and is therefore also known as vWF cleavage protease.

How should I choose among different ADAMTS13?

Our experts will recommend suitable products for you based on your research needs.

What diseases is ADAMTS13 involved in?

ADAMTS13 is involved in the study of diseases such as chronic kidney disease and diabetes.